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Your search keyword '"V M, Borovkova"' showing total 4 results
Start Over Author "V M, Borovkova" Topic humans
4 results on '"V M, Borovkova"'

1. [The dynamics of immunoglobulin E in volunteers immunized with a meningococcal group-B polysaccharide-protein vaccine]

Author

V B, Gervazieva, I A, Basnak'ian, N N, Aleksakhina, V I, Karabak, V M, Borovkova, V M, Kolenko, T A, Chulok, and V V, Sveranovskaia

Subjects
Time Factors, Antibody Specificity, Immunoglobulin G, Bacterial Vaccines, Polysaccharides, Bacterial, Immunization, Secondary, Humans, Immunization, Immunoglobulin E, Neisseria meningitidis, Bacterial Outer Membrane Proteins
Published
1994

2. [The immunological activity of a meningococcal serogroup-B polysaccharide-protein vaccine with a prolonged storage time in single administration]

Author

I A, Basnak'ian, A P, Alliluev, V I, Kuvakina, N N, Aleksakhina, O V, Kotel'nikova, T A, Chulok, V i, Karabak, V M, Borovkova, I I, Valerius, and I L, Gofman

Subjects
Time Factors, Drug Storage, Bacterial Vaccines, Polysaccharides, Bacterial, Humans, Neisseria meningitidis, Antibodies, Bacterial, Bacterial Outer Membrane Proteins
Published
1994

3. [The reactogenicity and antigenic activity of a meningococcal group B vaccine made from a natural complex of the specific polysaccharide and outer membrane proteins]

Author

I A, Basnak'ian, A P, Alliluev, V I, Kuvakina, L A, Levina, L I, Krasnoproshina, O V, Kotel'nikova, V I, Karabak, A M, Mordvitskiĭ, V M, Borovkova, and N N, Aleksakhina

Subjects
Adult, Male, Antigens, Bacterial, Time Factors, Polysaccharides, Bacterial, Brain, Immunoglobulin E, Neisseria meningitidis, Antibodies, Bacterial, Hemagglutinins, Bacterial Vaccines, Drug Evaluation, Humans, Immunization, Bacterial Outer Membrane Proteins
Abstract

Group B meningococcal vaccine consisting of the natural complex of specific polysaccharide and outer membrane protein (OMP) has been shown to be moderately reactogenic, safe with respect to the effect of undermining tolerance to human brain tissue antigens and to produce no allergization of humans. The vaccine under study possesses antigenic activity: (a) immunization with this vaccine ensures the fourfold rise of the level of antibodies to the group-specific polysaccharide of group B meningococcus in about 80% of persons with the initially low level of antibodies, this percentage being retained during the whole period of observation, i. e. 85 days; (b) the vaccine enhances the level of antibodies to meningococcal OMP, determined in the enzyme immunoassay and the passive hemagglutination test; (c) these data are indicative of the expediency of immunizing the risk groups of persons with the initially low level of antibodies.

Published
1990

4. [Antibody response to capsular polysaccharide antigen in an infection caused by meningococcus serogroup B in children]

Author

N N, Kostiukova, I A, Basnak'ian, N N, Aleksakhina, V M, Borovkova, and S A, Derkach

Subjects
Antigen-Antibody Reactions, Meningococcal Infections, Antigens, Bacterial, Epitopes, Erythrocytes, Time Factors, Polysaccharides, Bacterial, Humans, Hemagglutination Tests, Neisseria meningitidis, Child, Antibodies, Bacterial
Abstract

The continuous synchronous cultivation of serogroup B meningococci and the use of the selected clones of producer strains has made it possible to obtain the serologically active preparation of the group-specific antigen from the culture in the exponential phase. The erythrocyte diagnosticum produced on the basis of this preparation has permitted the detection of group-specific antibodies in the sera of immunized rabbits and children with generalized infection caused by serogroup B meningococci. The intensity of immune response depends on the age of children. This new technique of the passive hemagglutination test is recommended for the confirmation of generalized infection caused by serogroup B meningococci.

Published
1987

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