13 results on '"Vera Lennie"'
Search Results
2. Effect of Empagliflozin on Left Ventricular Volumes in Patients With Type 2 Diabetes, or Prediabetes, and Heart Failure With Reduced Ejection Fraction (SUGAR-DM-HF)
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Vera Lennie, Aleksandra Radjenovic, Victor Chong, Kirsty Wetherall, Steven Sourbron, Naveed Sattar, Colin J. Petrie, Liz Coyle, Catherine Labinjoh, Katriona Brooksbank, Giles Roditi, John J.V. McMurray, Matthew M.Y. Lee, Rosemary Woodward, John R. Petrie, Iain A. Speirits, John G. Dreisbach, Clare Murphy, Pardeep S. Jhund, Kieran F. Docherty, Colin Berry, Alex McConnachie, Paul Welsh, Kenneth Mangion, Patrick B. Mark, Ross T. Campbell, Mark C. Petrie, and Ninian N. Lang
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Male ,medicine.medical_specialty ,Type 2 diabetes ,030204 cardiovascular system & hematology ,Prediabetic State ,03 medical and health sciences ,0302 clinical medicine ,Double-Blind Method ,Glucosides ,Physiology (medical) ,Internal medicine ,Diabetes mellitus ,medicine ,Empagliflozin ,Humans ,030212 general & internal medicine ,Prediabetes ,Benzhydryl Compounds ,Ventricular remodeling ,Sodium-Glucose Transporter 2 Inhibitors ,Aged ,Heart Failure ,Ejection fraction ,medicine.diagnostic_test ,Ventricular Remodeling ,business.industry ,Magnetic resonance imaging ,Stroke Volume ,medicine.disease ,Diabetes Mellitus, Type 2 ,Heart failure ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background: Sodium-glucose cotransporter 2 inhibitors reduce the risk of heart failure hospitalization and cardiovascular death in patients with heart failure and reduced ejection fraction (HFrEF). However, their effects on cardiac structure and function in HFrEF are uncertain. Methods: We designed a multicenter, randomized, double-blind, placebo-controlled trial (the SUGAR-DM-HF trial [Studies of Empagliflozin and Its Cardiovascular, Renal and Metabolic Effects in Patients With Diabetes Mellitus, or Prediabetes, and Heart Failure]) to investigate the cardiac effects of empagliflozin in patients in New York Heart Association functional class II to IV with a left ventricular (LV) ejection fraction ≤40% and type 2 diabetes or prediabetes. Patients were randomly assigned 1:1 to empagliflozin 10 mg once daily or placebo, stratified by age ( Results: From April 2018 to August 2019, 105 patients were randomly assigned: mean age 68.7 (SD, 11.1) years, 77 (73.3%) male, 82 (78.1%) diabetes and 23 (21.9%) prediabetes, mean LV ejection fraction 32.5% (9.8%), and 81 (77.1%) New York Heart Association II and 24 (22.9%) New York Heart Association III. Patients received standard treatment for HFrEF. In comparison with placebo, empagliflozin reduced LV end-systolic volume index by 6.0 (95% CI, –10.8 to –1.2) mL/m 2 ( P =0.015). There was no difference in LV global longitudinal strain. Empagliflozin reduced LV end-diastolic volume index by 8.2 (95% CI, –13.7 to –2.6) mL/m 2 ( P =0.0042) and reduced N-terminal pro-B-type natriuretic peptide by 28% (2%–47%), P =0.038. There were no between-group differences in other cardiovascular magnetic resonance measures, diuretic intensification, Kansas City Cardiomyopathy Questionnaire Total Symptom Score, 6-minute walk distance, or B-lines. Conclusions: The sodium-glucose cotransporter 2 inhibitor empagliflozin reduced LV volumes in patients with HFrEF and type 2 diabetes or prediabetes. Favorable reverse LV remodeling may be a mechanism by which sodium-glucose cotransporter 2 inhibitors reduce heart failure hospitalization and mortality in HFrEF. Registration: URL: https://www.clinicaltrials.gov . Unique identifier: NCT03485092.
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- 2021
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3. The Chief Scientist Office Cardiovascular and Pulmonary Imaging in SARS Coronavirus disease-19 (CISCO-19) study
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Kevin G. Blyth, Peter Kellman, Ryan Wereski, David Corcoran, Naveed Sattar, Peter W. Macfarlane, Andrew Morrow, Antonia Ho, Catherine Bagot, Colin Church, Sylvia Wright, Ninian N. Lang, Sharon Kean, Vera Lennie, Kenneth Mangion, David J Lowe, Colin Berry, Giles Roditi, Hannah Bayes, Robert Sykes, Rhian M. Touyz, Christian Delles, Lynsey Gillespie, Alex McConnachie, and Douglas Grieve
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medicine.medical_specialty ,Time Factors ,Myocarditis ,Heart Diseases ,Physiology ,Review ,Disease ,030204 cardiovascular system & hematology ,Kidney ,Multimodal Imaging ,Electrocardiography ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Internal medicine ,Physiology (medical) ,Troponin I ,medicine ,Humans ,AcademicSubjects/MED00200 ,Clinical significance ,Longitudinal Studies ,Prospective Studies ,030212 general & internal medicine ,Myocardial infarction ,Lung ,medicine.diagnostic_test ,SARS-CoV-2 ,business.industry ,COVID-19 ,Convalescence ,Heart ,Magnetic resonance imaging ,medicine.disease ,Clinical trial ,Scotland ,Research Design ,Host-Pathogen Interactions ,Kidney Diseases ,business ,Cardiology and Cardiovascular Medicine ,Cohort study - Abstract
Background COVID-19 is typically a primary respiratory illness with multisystem involvement. The prevalence and clinical significance of cardiovascular and multisystem involvement in COVID-19 remain unclear. Methods This is a prospective, observational, multicentre, longitudinal, cohort study with minimal selection criteria and a near-consecutive approach to screening. Patients who have received hospital care for COVID-19 will be enrolled within 28 days of discharge. Myocardial injury will be diagnosed according to the peak troponin I in relation to the upper reference limit (URL, 99th centile) (Abbott Architect troponin I assay; sex-specific URL, male: >34 ng/L; female: >16 ng/L). Multisystem, multimodality imaging will be undertaken during the convalescent phase at 28 days post-discharge (Visit 2). Imaging of the heart, lung, and kidneys will include multiparametric, stress perfusion, cardiovascular magnetic resonance imaging, and computed tomography coronary angiography. Health and well-being will be assessed in the longer term. The primary outcome is the proportion of patients with a diagnosis of myocardial inflammation. Conclusion CISCO-19 will provide detailed insights into cardiovascular and multisystem involvement of COVID-19. Our study will inform the rationale and design of novel therapeutic and management strategies for affected patients. Clinical trial registration ClinicalTrials.gov identifier NCT04403607.
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- 2020
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4. Right Atrial Indexed Volume in Healthy Adult Population: Reference Values for Two-Dimensional and Three-Dimensional Echocardiographic Measurements
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Joel Moreno, Laura Domínguez-Perez, Vera Lennie, Juan Guinea, Nellys Campos, Alberto de Agustín, Patricia Mahía, Miguel Angel García-Fernández, Maribel Quezada, Adriana Saltijeral, Carlos Macaya, Pedro Marcos-Alberca, and Leopoldo Pérez de Isla
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Male ,medicine.medical_specialty ,Intraclass correlation ,Echocardiography, Three-Dimensional ,Adult population ,Sensitivity and Specificity ,Right atrial ,Reference Values ,Linear regression ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Heart Atria ,Prospective cohort study ,Observer Variation ,Body surface area ,business.industry ,Reproducibility of Results ,Organ Size ,Middle Aged ,Atrial Function ,Surgery ,Spain ,Reference values ,Female ,Cardiology and Cardiovascular Medicine ,Nuclear medicine ,business ,Volume (compression) - Abstract
Background Current guidelines do not recommend routine assessment of right atrial volume due to the lack of standardized data. Three-dimensional wall-motion tracking (3D-WMT) is a new technology that allows us to calculate volumes without any geometric assumptions. The aim of this study was to define the indexed reference values for two-dimensional echocardiography (2D-echo) and 3D-WMT in adult healthy population and to assess the intermethod, intra- and interobserver agreement. Methods Prospective study. Nonselected healthy subjects were enrolled. Every patient underwent a 2D-echo and a 3D-WMT examination. 2D-echo right atrial volume was obtained by using the area-length method (A-L) from four- and two-chamber view. 3D-echo volumes were assessed by 3D-WMT. Values were indexed by the patient's body surface area. Results Sixty consecutive healthy subjects were enrolled. Mean age was 57 ± 12-years old and 27 patients (45%) were male. Average indexed right atrial volume obtained by 2D-echo and 3D-echo was 16.76 ± 8.15 mL/m2 and 19.05 ± 6.87 mL/m2, respectively. Univariate linear regression analysis between 2D-echo and 3D-echo right atrial volumes shows a weak correlation between right atrial volume obtained with 2D-echo compared with 3D-WMT (r = 0.29, CI 95% 0.029–0.66, P = 0.033). The agreement analysis shows a similar result (intraclass correlation coefficient [ICC] = 0.28). The intra- and interobserver agreement analysis showed a better agreement when using 3D-WMT. Conclusions This is the first study that reports the reference indexed right atrial volume values by means of 2D-echo and 3D-echo in healthy population. 3D-WMT is a feasible and reproducible method to determine right atrial volume.
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- 2013
5. Negative Blood Culture Infective Endocarditis in the Elderly: Long-Term Follow-Up
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Carlos Macaya, Vera Lennie, José Manuel Ribera, Leopoldo Pérez de Isla, Jorge Vázquez, and José Luis Zamorano
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Male ,Aging ,medicine.medical_specialty ,Fever ,Heart disease ,Leukocytosis ,Long term follow up ,Internal medicine ,Humans ,Medicine ,Endocarditis ,Prospective Studies ,Aged ,Ultrasonography ,Heart Murmurs ,Negative blood culture ,business.industry ,Endocarditis, Bacterial ,Prognosis ,medicine.disease ,Endocardial disease ,Infective endocarditis ,Splenomegaly ,Cardiology ,Female ,Geriatrics and Gerontology ,business ,Follow-Up Studies - Abstract
Background and Aim: Since the appearance of transesophageal echocardiography, the long-term prognosis of patients with negative blood culture infective endocarditis (NBCIE) has been found to be similar to that of patients with positive blood culture infective endocarditis (PBCIE). Nevertheless, the prognostic implications of NBCIE in the elderly (>65 years) has not, to date, been well documented. Our aim was to study the long-term prognosis of elderly patients with NBCIE and compare it with that of elderly patients with PBCIE. Methods: Our study group was composed of 60 consecutive patients >65 years old with a diagnosis of IE (confirmed by vegetation analysis or following Duke’s criteria). Every patient underwent transthoracic and transesophageal echocardiography. Fifty patients (83.3%) had PBCIE and 10 (16.7%) had NBCIE. All patients were followed up long-term, and the study end point was a composite one of death or need for valvular heart surgery. Results: Mean age was 72.9 ± 5 years (56.7% male). Similar clinical and echocardiographic characteristics were found in both groups. Global mortality, need for surgery, predisposing factors and infection location were also similar in both groups. In addition, no differences were found in the long-term prognosis (log rank p = 0.29). Conclusions: In our series, the long-term prognosis in elderly patients with IE is independent of the presence of a negative or positive blood culture. Thus, age cannot be considered an independent risk factor of negative outcome in elderly patients with NBCIE.
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- 2007
6. Relationship between endothelin-1 levels and pulmonary arterial hypertension in HIV-infected patients
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Vera Lennie, Victoria Moreno, Eulalia Valencia, Luz M. Carbonero, Rocío Toro, Alipio Mangas, Eugenia Vispo, Mariola López Vazquez de la Torre, Cristina Arce, Maribel Q. Feijoo, and Carlos Almería
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Adult ,Male ,medicine.medical_specialty ,Hypertension, Pulmonary ,Immunology ,Population ,HIV Infections ,Gastroenterology ,Interquartile range ,Internal medicine ,medicine ,Immunology and Allergy ,Humans ,Pulmonary pathology ,education ,education.field_of_study ,Endothelin-1 ,business.industry ,Case-control study ,Middle Aged ,medicine.disease ,Infectious Diseases ,Blood pressure ,Pathophysiology of hypertension ,Case-Control Studies ,Cohort ,Female ,business ,Viral load ,Biomarkers - Abstract
Objective: Pulmonary arterial hypertension (PAH) is a progressive, fatal disease with average survival of less than 3 years if left untreated. It is most common in patients infected with HIV. Although the pathogenesis in this population is not fully understood, it is thought that HIV infection, through the immune response and release of different inflammatory mediators such as endothelin-1, may contribute directly to endothelial damage. Our objective was to quantify endothelin-1 levels in HIV-infected patients and determine whether or not there is an association between this marker and PAH. Design: A case-control study in patients attending an infectious diseases clinic. Methods: The sample was composed of 79 patients divided into three groups: 23 HIV patients with PAH (HIV+/PAH+), 45 HIV patients without PAH (HIV+/PAH−) and a control group of 11 healthy individuals. The ratio between the HIV+/PAH− and HIV+/PAH+ groups was 2 : 1. Patients were matched by age, sex, risk group and viral load; the control group by age and sex. All patients had blood taken for endothelin-1 plasma quantification. Results: We found lower endothelin-1 levels in the controls than in the HIV+/PAH− group [0.71 pg/ml (interquartile range, IQR 0.54–0.94) vs. 1.13 pg/ml (IQR 0.87–1.38); P = 0.005] and the HIV+/PAH+ cohort [1.16 pg/ml (IQR 0.86–2.37); P = 0.003]. Patients with severe PAH had higher endothelin-1 levels [2.94 pg/ml (IQR 1.81–6.33)] than patients with mild and moderate PAH. Conclusion: Plasma endothelin-1 levels are higher in HIV patients with PAH than in the HIV-noninfected population and levels increase with the severity of the PAH.
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- 2014
7. What to do with an atrial thrombus?
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Rocío Carda, Viviana Serra, José Luis Zamorano, Carlos Almería, and Vera Lennie
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Pacemaker, Artificial ,medicine.medical_specialty ,Percutaneous ,Heart Diseases ,medicine.medical_treatment ,Vena Cava, Inferior ,Right atrial ,Fatal Outcome ,Atrial Fibrillation ,Epidemiology ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Heart Atria ,cardiovascular diseases ,Surgical treatment ,Aged, 80 and over ,business.industry ,Cardiac Pacing, Artificial ,Stent ,Thrombosis ,Atrial Thrombus ,General Medicine ,Surgery ,Right Atrial Thrombus ,cardiovascular system ,Female ,Stents ,Radiology ,Operative risk ,Cardiology and Cardiovascular Medicine ,business ,Echocardiography, Transesophageal - Abstract
This case report is about an 84-year-old woman admitted with right atrial thrombus attached to a pacemaker lead, diagnosed by transesophageal echocardiography. Surgical treatment was rejected due to the high operative risk, and percutaneous stenting was performed with success; unfortunately, the outcome was fatal and the patient died. We review here the clinical features of right atrial thrombi, including the epidemiology, clinical manifestations, diagnosis, and treatment, which is sometimes controversial.
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- 2008
8. Combined use of OCT and IVUS in spontaneous coronary artery dissection
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Carlos Macaya, Fernando Alfonso, Rosana Hernández, Jaime Dutary, Javier Escaned, Nieves Gonzalo, Jorge Sandoval, Pilar Jiménez-Quevedo, Vera Lennie, Manuel Paulo, Miguel Medina, and Camino Bañuelos
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Adult ,Male ,medicine.medical_specialty ,genetic structures ,Combined use ,Spontaneous coronary artery dissection (SCAD) ,Multimodal Imaging ,Aneurysm ,Percutaneous Coronary Intervention ,Optical coherence tomography ,Predictive Value of Tests ,Intravascular ultrasound ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Artery dissection ,Ultrasonography, Interventional ,Hematoma ,medicine.diagnostic_test ,business.industry ,Coronary Thrombosis ,Coronary Aneurysm ,Middle Aged ,medicine.disease ,Coronary Vessels ,eye diseases ,Aortic Dissection ,Radiology Nuclear Medicine and imaging ,Female ,Stents ,sense organs ,Tomography ,Radiology ,business ,Scad ,Cardiology and Cardiovascular Medicine ,Tomography, Optical Coherence - Abstract
SPONTANEOUS CORONARY ARTERY DISSECTION (SCAD) REPRESENTS A DIAGNOSTIC CHALLENGE [(1,2)][1]. In this study, we used a combined imaging strategy, intravascular ultrasound (IVUS) and optical coherence tomography (OCT), in 8 patients with SCAD. The diagnosis of SCAD required the visualization of an
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- 2013
9. Prevalence and risk factors associated with pulmonary hypertension in HIV-infected patients on regular follow-up
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Vicente Soriano, Victoria Moreno, José Luis Zamorano, Leopoldo Pérez de Isla, Carlos Almería, Maribel Quezada, Vera Lennie, Eulalia Valencia, Luz Martín-Carbonero, and Eugenia Vispo
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Adult ,Male ,medicine.medical_specialty ,Hypertension, Pulmonary ,Immunology ,Comorbidity ,Men who have sex with men ,Hepatitis B, Chronic ,Risk Factors ,Internal medicine ,Antiretroviral Therapy, Highly Active ,medicine ,Diabetes Mellitus ,Prevalence ,Immunology and Allergy ,Humans ,Acquired Immunodeficiency Syndrome ,business.industry ,Smoking ,Hepatitis C ,Odds ratio ,Hepatitis B ,Hepatitis C, Chronic ,Middle Aged ,Viral Load ,medicine.disease ,Pulmonary hypertension ,Confidence interval ,CD4 Lymphocyte Count ,Infectious Diseases ,Spain ,HIV-1 ,Female ,business ,Viral load - Abstract
Background Pulmonary arterial hypertension (PAH) is uncommon among HIV-positive patients. However, it is a potentially life-threatening condition. Transthoracic echocardiography (TTE) is a noninvasive tool validated for PAH screening. The aim of our study was to establish the prevalence and factors associated with PAH in HIV-infected patients. Methods Consecutive HIV-infected individuals attended at one HIV reference clinic in Madrid, Spain, during year 2011 were examined. Demographics and clinical data were recorded and a Doppler echocardiography was performed in all individuals. PAH was considered when right ventricular pressure was more than 35 mmHg (mild if 65 mmHg). Results Three hundred and ninety-two individuals were examined (83.4% men, median age 47 years, 53% were men who have sex with men and 53% former intravenous drug addicts). Overall, 84% were on HAART, 76% had undetectable HIV viral load and median CD4 cell counts were 577 cells/μl. Cardiovascular risk factors were smoking 50%, arterial hypertension 16% and diabetes mellitus 9%. A total of 28.5 and 4.8% had chronic hepatitis C (CHC) and 4.8% chronic hepatitis B, respectively. PAH was diagnosed in 9.9% of patients (6.4% mild, 2.8% moderate and 0.8% severe). Multivariate logistic regression analysis [odds ratio (OR), 95% confidence interval (CI)] showed that detectable plasma HIV-RNA [OR, 3.3; 95% CI, 1.04-10], CHC [OR, 3.1; 95% CI 1.2-8.2] and female sex [OR, 2.9; 95% CI, 1.04-8.3] were independently associated with PAH. Conclusion The prevalence of PAH HIV-infected patients on regular follow-up approaches 10%, being moderate-severe in nearly 4% of cases. Patients with CHC and/or uncontrolled HIV replication exhibit a higher risk of PAH.
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- 2012
10. Spontaneous coronary artery dissection: long-term follow-up of a large series of patients prospectively managed with a 'conservative' therapeutic strategy
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Fernando, Alfonso, Manuel, Paulo, Vera, Lennie, Jaime, Dutary, Esther, Bernardo, Pilar, Jiménez-Quevedo, Nieves, Gonzalo, Javier, Escaned, Camino, Bañuelos, María J, Pérez-Vizcayno, Rosana, Hernández, and Carlos, Macaya
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Male ,Time Factors ,Incidence ,Coronary Aneurysm ,Anticoagulants ,Coronary Artery Disease ,Middle Aged ,Coronary Angiography ,Coronary Vessels ,Survival Analysis ,Statistics, Nonparametric ,Aortic Dissection ,Spain ,Humans ,Female ,Prospective Studies ,Angioplasty, Balloon, Coronary ,Platelet Aggregation Inhibitors - Abstract
This study sought to assess the long-term clinical outcome of patients with spontaneous coronary artery dissection (SCD) managed with a conservative strategy.SCD is a rare, but challenging, clinical entity.A prospective protocol, including a conservative management strategy, was followed. Revascularization was only considered in cases with ongoing/recurrent ischemia. Inflammatory/immunologic markers were systematically obtained.Forty-five consecutive patients (incidence 0.27%) were studied during a 6-year period. Of these, 27 patients (60%) had "isolated" SCD (I-SCD), and 18 had SCD associated with coronary artery disease (A-SCD). Age was 53 ± 11 years, and 26 patients were female. Most patients presented with an acute myocardial infarction. SCD had a diffuse angiographic pattern (length: 31 ± 23 mm). In 11 patients, the diagnosis was confirmed by intracoronary imaging techniques. Sixteen patients (35%) required revascularization during initial admission. One patient died after surgery, but no additional patient experienced recurrent myocardial infarction. No significant inflammatory/immunologic abnormalities were detected. At follow-up (median 730 days), only 3 patients presented with adverse events (1 died of congestive heart failure, and 2 required revascularization). No patient experienced a myocardial infarction or died suddenly. Event-free survival was similar (94% and 88%, respectively) in patients with I-SCD and A-SCD. Notably, at angiographic follow-up, spontaneous "disappearance" of the SCD image was found in 7 of 13 (54%) patients.In this large prospective series of consecutive patients with SCD, a "conservative" therapeutic strategy provided excellent long-term prognosis. Clinical outcome was similar in patients with I-SCD and A-SCD. The natural history of SCD includes spontaneous healing with complete resolution.
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- 2012
11. [Area strain: normal values for a new parameter in healthy people]
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Leopoldo, Pérez de Isla, Mariángel, Millán, Vera, Lennie, Maribel, Quezada, Juan, Guinea, Carlos, Macaya, and José, Zamorano
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Adult ,Male ,Observer Variation ,Echocardiography ,Reference Values ,Risk Factors ,Echocardiography, Three-Dimensional ,Image Processing, Computer-Assisted ,Humans ,Female ,Heart ,Middle Aged ,Ventricular Function, Left - Abstract
The echocardiographic technology known as three-dimensional wall motion tracking offers three-dimensional images of the myocardium and provides multiple measures of deformation, one of which is known as "area strain" (AS), which combines left ventricular longitudinal and circumferential deformations. Our aim was to describe the normal maximum systolic reference AS value in a sample of healthy subjects. Sixty consecutive subjects without known cardiovascular risk factors or diseases were enrolled, and left ventricular AS was measured. Overall mean AS was -38.87 ± 5.89%. Mean values at the level of the basal, middle, and apical segments were -38.42 ± 7.58%, -38.74 ± 6.34%, and -43.18 ± 12.81%, respectively. Thus, our results show for the first time the reference values for AS in healthy subjects.
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- 2010
12. Distortion of the QRS in elderly patients with myocardial infarction
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Juan C, García-Rubira, Iván, Núnez-Gil, Rafael, García-Borbolla, Vera, Lennie, María C, Manzano, Miguel A, Cobos, Leopoldo Pérez, de Isla, Antonio, Fernández-Ortiz, and Carlos, Macaya
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Male ,Time Factors ,Age Factors ,Myocardial Infarction ,Shock, Cardiogenic ,Arrhythmias, Cardiac ,Middle Aged ,Risk Assessment ,Electrocardiography ,Logistic Models ,Treatment Outcome ,Heart Conduction System ,Predictive Value of Tests ,Risk Factors ,Odds Ratio ,Humans ,Female ,Thrombolytic Therapy ,Hospital Mortality ,Angioplasty, Balloon, Coronary ,Aged - Abstract
Distortion of the terminal portion of the QRS in the initial electrocardiogram (ECG) is a strong predictor of adverse outcome in myocardial infarction. Our purpose is to assess the relationship of distortion of QRS and other ECG characteristics with older age.We analysed 634 consecutive patients (age 62.6 +/- 13.7, 77% male) admitted in the first 12 hours of ST-elevation myocardial infarction. Two groups of age were defined:75 years-old andor= 75 years-old. Additionally, we defined two ECG groups according to the presence of ST segment elevation with distortion of the terminal portion of the QRS in two or more adjacent leads (QRS+) or the absence of this pattern (QRS-). Older people had more often QRS+ (30% vs. 20%, p = 0.023). The older group with QRS+ had an in-hospital mortality of 18%, vs. 7% with QRS- (p = 0.04), and an incidence of major adverse events of 40% vs. 14% (p = 0.002). In the multivariate analysis, ageor= 75 years was an independent predictor of distortion of the QRS (odds ratio 2.1, 1.2-4.9, p = 0.016).The distortion of the terminal portion of the QRS in myocardial infarction is more frequent in elderly people, and is significantly related to adverse prognosis. This ECG finding can be helpful to promptly stratify the risk in elderly patients.
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- 2009
13. Asymptomatic coronary artery aneurysms: echocardiography, cardiac magnetic resonance, and coronariography assessment
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Jose Alberto de Agustin, Vera Lennie, and José Luis Rodrigo
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Male ,medicine.medical_specialty ,Radiography ,Physical examination ,Coronary Angiography ,Asymptomatic ,Internal medicine ,medicine ,Humans ,cardiovascular diseases ,Coronary artery aneurysm ,medicine.diagnostic_test ,business.industry ,Vascular disease ,Coronary Aneurysm ,Magnetic resonance imaging ,Middle Aged ,medicine.disease ,medicine.anatomical_structure ,Echocardiography ,cardiovascular system ,Cardiology ,Radiology ,medicine.symptom ,Transthoracic echocardiogram ,Cardiology and Cardiovascular Medicine ,business ,Magnetic Resonance Angiography ,circulatory and respiratory physiology ,Artery - Abstract
An asymptomatic 55-year-old man with a previous history of hypertension and dyslipidaemia was referred to our clinic as a result of the finding of an enlarged cardiac silhouette in a routine chest radiography. His physical examination and electrocardiogram was unremarkable. Transthoracic echocardiogram revealed …
- Published
- 2008
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