1. Palliative care delivery according to age in 12,000 women with metastatic breast cancer: Analysis in the multicentre ESME-MBC cohort 2008-2016
- Author
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Thomas Bachelot, Lionel Uwer, Marianne Leheurteur, Anne Patsouris, Florence Dalenc, Virginie Perotin, Laurence Vanlemmens, Jean S Frenel, Camille Sabathe, Carole Bouleuc, Marie Ange Mouret-Reynier, Suzette Delaloge, C. Courtinard, Anne Jaffre, Anthony Gonçalves, Jean Marc Ferrero, Isabelle Desmoulins, Matthieu Frasca, Jean C Eymard, Thierry Petit, Simone Mathoulin-Pélissier, Angéline Galvin, Christelle Levy, Véronique Diéras, Michaël Chevrot, Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), UNICANCER, Centre Paul Strauss, and CRLCC Paul Strauss
- Subjects
0301 basic medicine ,Cancer Research ,medicine.medical_specialty ,Palliative care ,[SDV]Life Sciences [q-bio] ,Psychological intervention ,Breast Neoplasms ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,History, 21st Century ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Older patients ,Internal medicine ,parasitic diseases ,medicine ,Humans ,cardiovascular diseases ,Neoplasm Metastasis ,ComputingMilieux_MISCELLANEOUS ,Aged ,Inpatient care ,business.industry ,Palliative Care ,Age Factors ,Cancer ,EPICENE ,medicine.disease ,Metastatic breast cancer ,Confidence interval ,3. Good health ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,Cohort ,Female ,business - Abstract
Patients with metastatic breast cancer (MBC) often require inpatient palliative care (IPC). However, mounting evidence suggests age-related disparities in palliative care delivery. This study aimed to assess the cumulative incidence function (CIF) of IPC delivery, as well as the influence of age.The national ESME (Epidemio-Strategy-Medical-Economical)-MBC cohort includes consecutive MBC patients treated in 18 French Comprehensive Cancer Centres. ICD-10 palliative care coding was used for IPC identification.Our analysis included 12,375 patients, 5093 (41.2%) of whom were aged 65 or over. The median follow-up was 41.5 months (95% confidence interval [CI], 40.5-42.5). The CIF of IPC was 10.3% (95% CI, 10.2-10.4) and 24.8% (95% CI, 24.7-24.8) at 2 and 8 years, respectively. At 2 years, among triple-negative patients, young patients (65 yo) had a higher CIF of IPC than older patients after adjusting for cancer characteristics, centre and period (65+/65: β = -0.05; 95% CI, -0.08 to -0.01). Among other tumour sub-types, older patients received short-term IPC more frequently than young patients (65+/65: β = 0.02; 95% CI, 0.01 to 0.03). At 8 years, outside large centres, IPC was delivered less frequently to older patients adjusted to cancer characteristics and period (65+/65: β = -0.03; 95% CI, -0.06 to -0.01).We found a relatively low CIF of IPC and that age influenced IPC delivery. Young triple-negative and older non-triple-negative patients needed more short-term IPCs. Older patients diagnosed outside large centres received less long-term IPC. These findings highlight the need for a wider implementation of IPC facilities and for more age-specific interventions.
- Published
- 2020