1. Successful treatment of central nervous system lymphoproliferative disorder in a kidney-pancreas and stem cell transplanted patient using intrathecal rituximab
- Author
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Kristof Egervari, Yves Chalandon, Stavroula Masouridi, Anne-Claire Mamez, Maria Vargas, Karine Hadaya, and Maria Anastasiou
- Subjects
Oncology ,Central Nervous System ,medicine.medical_specialty ,Central nervous system ,Neuroimaging ,ddc:616.07 ,Intrathecal ,Kidney ,ddc:616.0757 ,Organ transplantation ,Haematology (drugs and medicines) ,Antibodies, Monoclonal, Murine-Derived ,Internal medicine ,hemic and lymphatic diseases ,Malignant disease and immunosuppression ,medicine ,Humans ,Pancreas ,ddc:616 ,business.industry ,Stem Cells ,General Medicine ,Lymphoproliferative Disorders / drug therapy ,Lymphoproliferative Disorders ,Transplantation ,CNS cancer ,medicine.anatomical_structure ,surgical procedures, operative ,Rituximab ,Stem cell ,Haematology (incl blood transfusion) ,business ,medicine.drug - Abstract
Central nervous system lymphoproliferative disorder (CNS-PTLD) after organ transplant is a unique clinicopathological entity and is associated with poor survival rates. When the CNS is involved, intravenous rituximab might not be the treatment of choice, due to its poor CNS penetration. However, intrathecal (IT) administration of rituximab has shown to be safe and efficient in small studies and in case series. We report here the case of a patient with late development of CNS-PTLD after kidney-pancreas transplantation who achieved complete remission after surgical resection and four cycles of IT rituximab and we provide a review of the literature for this treatment option.
- Published
- 2023