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1. Senataxin helicase, the causal gene defect in ALS4, is a significant modifier of C9orf72 ALS G4C2 and arginine-containing dipeptide repeat toxicity.

2. Clonally expanded CD8 T cells characterize amyotrophic lateral sclerosis-4

3. BRCA2 associates with MCM10 to suppress PRIMPOL-mediated repriming and single-stranded gap formation after DNA damage.

4. Catalytically inactive, purified RNase H1: A specific and sensitive probe for RNA–DNA hybrid imaging

5. Optimized protocol for the identification of lipid droplet proteomes using proximity labeling proteomics in cultured human cells

6. APEX2 Proximity Proteomics Resolves Flagellum Subdomains and Identifies Flagellum Tip-Specific Proteins in Trypanosoma brucei

7. Wnt-inducible Lrp6-APEX2 interacting proteins identify ESCRT machinery and Trk-fused gene as components of the Wnt signaling pathway.

8. Proximity RNA Labeling by APEX-Seq Reveals the Organization of Translation Initiation Complexes and Repressive RNA Granules

9. Senataxin mutations elicit motor neuron degeneration phenotypes and yield TDP-43 mislocalization in ALS4 mice and human patients

10. Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells

11. Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis.

12. Mutation of senataxin alters disease-specific transcriptional networks in patients with ataxia with oculomotor apraxia type 2

13. Wnt-inducible Lrp6-APEX2 interacting proteins identify ESCRT machinery and Trk-fused gene as components of the Wnt signaling pathway

14. Identification of the 11-cis-specific retinyl-ester synthase in retinal Müller cells as multifunctional O-acyltransferase (MFAT)

15. Unique Ataxia-Oculomotor Apraxia 2 (AOA2) in Israel with Novel Variants, Atypical Late Presentation, and Possible Identification of a Poison Exon

16. Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

17. Evidence Supporting Substrate Channeling between Domains of Human PAICS: A Time-Course Analysis of

18. Mutation in senataxin alters the mechanism of R-loop resolution in amyotrophic lateral sclerosis 4

19. Translesion Synthesis across the

20. APEX2‐based Proximity Labeling of Atox1 Identifies CRIP2 as a Nuclear Copper‐binding Protein that Regulates Autophagy Activation

21. MTHFD2 promotes ovarian cancer growth and metastasis via activation of the STAT3 signaling pathway

22. CHSY1 is upregulated and acts as tumor promotor in gastric cancer through regulating cell proliferation, apoptosis, and migration

23. Xanthine Derivatives Reveal an Allosteric Binding Site in Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2)

24. [Genetic distribution in Chinese patients with hereditary peripheral neuropathy]

25. MTHFD2 promotes tumorigenesis and metastasis in lung adenocarcinoma by regulating AKT/GSK‐3β/β‐catenin signalling

26. Folate-mediated one-carbon metabolism: a targeting strategy in cancer therapy

27. FAN1, a DNA Repair Nuclease, as a Modifier of Repeat Expansion Disorders

28. Cisplatin-Mediated Upregulation of APE2 Binding to MYH9 Provokes Mitochondrial Fragmentation and Acute Kidney Injury

29. [Association of maternal

30. Hypoxia-regulated carbonic anhydrase IX (CAIX) protein is an independent prognostic indicator in triple negative breast cancer

31. Gliadin induced oxidative stress and altered cellular responses in human intestinal cells: An in‐vitro study to understand the cross‐talk between the transcription factor Nrf‐2 and multifunctional APE1 enzyme

32. Wnt-inducible Lrp6-APEX2 interacting proteins identify ESCRT machinery and Trk-fused gene as components of the Wnt signaling pathway

33. Therapeutic Targeting of Mitochondrial One-Carbon Metabolism in Cancer

34. Homozygosity mapping and next generation sequencing for the genetic diagnosis of hereditary ataxia and spastic paraplegia in consanguineous families

35. Artemisinin inhibits glycosaminoglycan chain synthesizing gene expression but not proliferation of human vascular smooth muscle cells

36. Autosomal Recessive Cerebellar Ataxias With Elevated Alpha‐Fetoprotein: Uncommon Diseases, Common Biomarker

37. Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington’s disease knock-in mice is blocked by Mlh1 knock-out

38. IgA Nephropathy Concomitant With Karyomegalic Interstitial Nephritis

39. RNA–protein interaction mapping via MS2- or Cas13-based APEX targeting

40. Gene expression profiles complement the analysis of genomic modifiers of the clinical onset of Huntington disease

41. The distinct manifestation of young-onset amyotrophic lateral sclerosis in China

42. Nucleolar RNA polymerase II drives ribosome biogenesis

43. Structural insight into DNA joining: from conserved mechanisms to diverse scaffolds

44. Clinical and genetic features of patients with amyotrophic lateral sclerosis in southern China

45. Mitochondrial genetic variation is enriched in G-quadruplex regions that stall DNA synthesis in vitro

46. Case report: a 58 -year -old man with small kidneys and elevated liver enzymes

47. Exome sequencing of individuals with Huntington’s disease implicates FAN1 nuclease activity in slowing CAG expansion and disease onset

48. ΔNp63-Senataxin circuit controls keratinocyte differentiation by promoting the transcriptional termination of epidermal genes

49. High prevalence of deleterious mutations in concomitant nonsyndromic cleft and outflow tract heart defects

50. New insights on familial colorectal cancer type X syndrome

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