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Start Over Author "Warner, Lindsey M." Topic humoral immunity
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1. MiR-23~27~24-mediated control of humoral immunity reveals a TOX-driven regulatory circuit in follicular helper T cell differentiation.

Author

Cheng-Jang Wu, Sunglim Cho, Hsi-Yuan Huang, Chun-Hao Lu, Russ, Jasmin, Cruz, Leilani O., da Cunha, Flavia Franco, Mei-Chi Chen, Ling-Li Lin, Warner, Lindsey M., Hsin-Kai Liao, Utzschneider, Daniel T., Quon, Sara, Berner, Jacqueline, Camara, Niels Olsen Saraiva, Zehn, Dietmar, Belmonte, Juan Carlos Izpisua, Li-Chen Chen, Shiang-Fu Huang, and Ming-Ling Kuo

Subjects
*INTERLEUKIN-27, *T helper cells, *T cell differentiation, *HUMORAL immunity, *SUPPRESSOR cells, *KILLER cells, *PHYSIOLOGY
Abstract

The article explores how Follicular helper T (TFH) cells are essential for generating protective humoral immunity. Topics discussed include thymocyte selection–associated HMG-box protein (TOX) was identified as a central transcription regulator in TFH cell development; TOX promotes the expression of multiple molecules that play critical roles in TFH cell differentiation and function; and understanding of the molecular mechanisms that govern the differentiation and function of TFH cells.

Published
2019

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