1. Co-Spray-Dried Urea Cross-Linked Hyaluronic Acid and Sodium Ascorbyl Phosphate as Novel Inhalable Dry Powder Formulation.
- Author
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Fallacara A, Busato L, Pozzoli M, Ghadiri M, Ong HX, Young PM, Manfredini S, and Traini D
- Subjects
- Administration, Inhalation, Aerosols, Anti-Inflammatory Agents administration & dosage, Ascorbic Acid administration & dosage, Ascorbic Acid chemistry, Cell Line, Tumor, Chemistry, Pharmaceutical, Cross-Linking Reagents chemistry, Desiccation methods, Drug Combinations, Drug Stability, Dry Powder Inhalers, Humans, Hyaluronic Acid administration & dosage, Lung Diseases drug therapy, Particle Size, Powders, Urea administration & dosage, Anti-Inflammatory Agents chemistry, Ascorbic Acid analogs & derivatives, Drug Compounding methods, Hyaluronic Acid chemistry, Urea chemistry
- Abstract
The pathogenesis and progression of several lung disorders is propagated by inflammatory and oxidative processes, which can be controlled by adjunctive inhaled therapies. The present study aimed to develop an inhalable dry powder formulation consisting of co-spray-dried urea-crosslinked hyaluronic acid and sodium ascorbyl phosphate (SD HA-CL-SAP), a novel combination which was recently shown to possess anti-inflammatory, antioxidant, and wound healing properties. Native HA and SAP were co-spray dried (SD HA-SAP) and evaluated as control formulation. Yield (Y%) and encapsulation efficiency (EE%) were 67.0 ± 4.8% and 75.5 ± 7.2% for SD HA-SAP, 70.0 ± 1.5% and 66.5 ± 5.7% for SD HA-CL-SAP, respectively. Both formulations were shown to be suitable for lung delivery in terms of morphology, particle size (median volumetric diameter ∼ 3.4 μm), physical and thermal stability, in vitro aerosol performance - respirable fraction: 30.5 ± 0.7% for SD HA-SAP and 35.3 ± 0.3% for SD HA-CL-SAP. SAP release was investigated using Franz cells and air-interface Calu-3 cell model (>90% of SAP transported within 4 h). The innovative SD HA-CL-SAP formulation holds potential as inhalable dry powder for the treatment of inflammatory lung disorders., (Copyright © 2019 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.)
- Published
- 2019
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