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The hydration of haloalkynes to give α-halomethyl ketones was achieved based on a combination of a Cu(OAc)2 catalyst and a TFA (trifluoroacetic acid) promoter. This is the first synthesis of chloro/bromo/iodo methyl ketones through a hydration reaction catalyzed by a recyclable catalytic system. The catalytic system has a wide substrate scope and excellent chemoselectivity, and the procedure can also be scaled up. [ABSTRACT FROM AUTHOR]

A general, efficient, and highly regioselective protocol with the use of a gold(I) complex catalytic system for the transformation of alkynylphosphonates into the corresponding β-ketophosphonates has been successfully developed. This method produces a variety of β-ketophosphonates with the advantages of mild reaction conditions, high functional-group tolerance, and excellent yields. [ABSTRACT FROM AUTHOR]

The Cu(OAc)2/TFA system can be recycled and reused for at least five times without loss of activity. [ABSTRACT FROM AUTHOR]

A novel and practical method for the synthesis of β-ketophosphonates through AgNO3-catalyzed hydration of alkynylphosphonates with a dramatic rate enhancement effect of methanol is developed. [ABSTRACT FROM AUTHOR]

An abstract of the article "Gold(I)-Catalyzed Hydration of Alkynylphosphonates: Efficient Access to β-Ketophosphonates" by L. Xie et al is presented.

The title reaction allows a simple and efficient access to a wide variety of α-halomethyl ketones. [ABSTRACT FROM AUTHOR]