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Your search keyword '"J. Troth"' showing total 2 results
Start Over Author "J. Troth" Topic hydrocarbons, fluorinated
2 results on '"J. Troth"'

1. Metabolism of 1,1,1,2,2-pentafluorohexane and 1,1-difluorocyclohexane by rat liver microsomes in vitro.

Author

Baker MH, Foster AB, Hegedus L, Jarman M, Rowlands MG, Coe PL, and Troth J

Subjects
Animals, Enzyme Induction drug effects, Hydroxylation, In Vitro Techniques, Male, Microsomes, Liver drug effects, Oxygenases biosynthesis, Phenobarbital pharmacology, Rats, Rats, Inbred Strains, Hydrocarbons, Fluorinated metabolism, Microsomes, Liver metabolism
Abstract

Metabolism of 1,1,1,2,2-pentafluorohexane with liver microsomes from phenobarbital-treated rats gave only one metabolite, namely, the 5-hydroxy derivative. Under similar conditions 1,1-difluorocyclohexane was metabolized to give mainly the 3- and 4-hydroxy derivatives in the ratio 1: approximately 5.5. The structures of these metabolites were established by chemical ionization (CI) and/or electron impact (EI) mass spectrometry and confirmed by synthesis in the case of 1,1-difluorocyclohexan-4-ol. Oxidation of 1,1-difluorocyclohexane with lead tetrakis(trifluoroacetate) also gave, inter alia, the 3- and 4-hydroxy derivatives. In saturated hydrocarbons complete replacement of hydrogen by fluorine at one particular carbon will not only block microsomal hydroxylation thereat but will also inhibit hydroxylation at neighbouring hydrogen-bearing carbons, (alpha almost completely, beta markedly, gamma slightly).

Published
1984
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2. Metabolism of 1,1,1,2,2-pentafluorohexane and 1,1-difluorocyclohexane by rat liver microsomesin vitro

Author

Paul L. Coe, Michael H. Baker, J. Troth, Martin G. Rowlands, Lajos Hegedus, Allan B. Foster, and Michael Jarman

Subjects
Male, Hydrocarbons, Fluorinated, Stereochemistry, Metabolite, In Vitro Techniques, Hydroxylation, Mass spectrometry, chemistry.chemical_compound, Animals, Spectroscopy, chemistry.chemical_classification, Chemical ionization, biology, Rats, Inbred Strains, Metabolism, biology.organism_classification, Rats, Hydrocarbon, chemistry, Microsoma, Enzyme Induction, Phenobarbital, Microsomes, Liver, Oxygenases, Microsome
Abstract

Metabolism of 1,1,1,2,2-pentafluorohexane with liver microsomes from phenobarbital-treated rats gave only one metabolite, namely, the 5-hydroxy derivative. Under similar conditions 1,1-difluorocyclohexane was metabolized to give mainly the 3- and 4-hydroxy derivatives in the ratio 1: approximately 5.5. The structures of these metabolites were established by chemical ionization (CI) and/or electron impact (EI) mass spectrometry and confirmed by synthesis in the case of 1,1-difluorocyclohexan-4-ol. Oxidation of 1,1-difluorocyclohexane with lead tetrakis(trifluoroacetate) also gave, inter alia, the 3- and 4-hydroxy derivatives. In saturated hydrocarbons complete replacement of hydrogen by fluorine at one particular carbon will not only block microsomal hydroxylation thereat but will also inhibit hydroxylation at neighbouring hydrogen-bearing carbons, (alpha almost completely, beta markedly, gamma slightly).

Published
1984

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