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[Display omitted] • Antibiotic coordination frameworks may lead to higher antimicrobial activity. • Solubility increase via antibiotic coordination frameworks. • Mechanochemistry for the synthesis of metallodrugs and antibiotic coordination frameworks. Even though antibiotics were a major breakthrough a few decades ago, leading to a drastic reduction of deaths caused by infectious diseases, this class of compounds is nowadays demanding for a new approach as their efficiency has been challenged. Different approaches have been explored to increase the effectiveness of the antibiotics. The development of bio-inspired metal–organic frameworks and antibiotic coordination frameworks have been revealing promising results, showing that these novel forms of already existing antibiotics can tune their properties at the same time that may also increase their antimicrobial activity, maintaining their stability and cytotoxicity. Amongst other results, it is worth to highlight that: (i) the coordination of potassium to azelaic acid led to an increased activity against the Gram-positive bacteria Staphylococcus aureus and Staphylococcus epidermidis responsible for skin infections; (ii) the coordination of transition and alkali earth metals (Ca(II), Zn(II), Mn(II), and Mg(II)) to quinolone antibiotics (nalidixic and pipemidic acids) revealed increased activity against different Gram-positive and Gram-negative bacteria. [ABSTRACT FROM AUTHOR]

The urge for the development of a more efficient antibiotic crystalline forms led us to the disclosure of new antibiotic coordination frameworks of pyrazinamide, a well-known drug used for the treatment of tuberculosis, with some of the novel compounds unravelling improved antimycobacterial activity. Mechanochemistry was the preferred synthetic technique to yield novel compounds, allowing the reproduction of a 1D zinc framework, the synthesis of a novel hydrogen bonding manganese framework, and three new compounds with silver. The structural characterization of the novel forms is presented along with stability studies. The increased antimicrobial activity of the new silver-based frameworks against Escherichia coli, Staphylococcus aureus, and Mycobacterium smegmatis is particularly relevant. [ABSTRACT FROM AUTHOR]