1. Effect of α-blockers on Handgrip Test Response of Diastolic Blood Pressure in Hypertensive, Benign Hypertrophy of Prostate Patients in a Therapeutics Clinic, Kolkata: A Cross-sectional Study.
- Author
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Samajdar SS, Mukherjee S, Gupta S, Saha D, Kayal A, Begum SA, Chatterjee N, Tripathi SK, Pal J, and Joshi SR
- Subjects
- Humans, Male, Cross-Sectional Studies, Middle Aged, Aged, Antihypertensive Agents therapeutic use, India, Prostatic Hyperplasia drug therapy, Prostatic Hyperplasia physiopathology, Prazosin pharmacology, Prazosin therapeutic use, Prazosin administration & dosage, Tamsulosin therapeutic use, Adrenergic alpha-1 Receptor Antagonists therapeutic use, Adrenergic alpha-1 Receptor Antagonists pharmacology, Blood Pressure drug effects, Hypertension drug therapy, Hypertension physiopathology, Hand Strength physiology
- Abstract
Background: The isometric handgrip (IHG) test is commonly used to detect sympathetic autonomic dysfunction. Tamsulosin, approved for the management of symptomatic benign prostatic hyperplasia (BPH), acts as an antagonist for α1-adrenergic receptors (α1-AR), whereas prazosin, an α
1 receptor blocker, being less selective than tamsulosin, is used as an antihypertensive agent clinically. Our objective was to investigate if there is a distinction in blood pressure (BP) increase during IHG exercise between individuals with essential hypertension taking tamsulosin compared to those taking prazosin., Materials and Methods: A cross-sectional observational study was performed on 50 subjects receiving tablet prazosin and 47 subjects receiving tamsulosin, who were asked to undergo an IHG test. Pre- and posttest BP was recorded for both the groups, and the difference in diastolic BP (DBP) (delta DBP) was compared between the groups and to their respective baseline values., Results: Post-IHG test, mean DBP was found to be 93.98 ± 9.13 mm Hg in the prazosin group and 101.00 ± 12.05 mm Hg in the tamsulosin group, respectively. The change of delta DBP in the tamsulosin group was significant, but the prazosin group showed an insignificant rise in DBP., Conclusion: Prazosin, being less selective than tamsulosin in terms of α1 receptor antagonism, showed suppression of BP during IHG. Tamsulosin demonstrates high selectivity for prostatic receptors while showing minimal affinity for vascular receptors. As a result, its impact on BP is expected to be minimal., (© Journal of the Association of Physicians of India 2024.)- Published
- 2024
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