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Your search keyword '"Silvia E. Ferreira-Melo"' showing total 2 results
Start Over Author "Silvia E. Ferreira-Melo" Topic hypertension
2 results on '"Silvia E. Ferreira-Melo"'

1. Transcranial direct current stimulation modulates autonomic nervous system and reduces ambulatory blood pressure in hypertensives

Author

Bruno Rodrigues, Catarina A. Barboza, Eliezer G. Moura, Gabriela Ministro, Silvia E. Ferreira-Melo, Javier B. Castaño, Olivia M. Ruberti, Rivadávio F. B. De Amorim, and Heitor Moreno

Subjects
hypertension, autonomic modulation, transcranial direct current stimulation (tdcs), ambulatory blood pressure measurement, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Purpose: Transcranial direct current stimulation (tDCS) seems to positively modulate the autonomic nervous system in different clinical conditions and healthy subjects; however, its effects on hypertensive (HTN) patients are not completely known. This study aimed to evaluate the effects of a tDCS or SHAM session (20 min) on blood pressure (BP) and autonomic variables of HTN patients. Materials and Methods: Subjects (n = 13) were randomly submitted to SHAM and tDCS sessions (1 week of washout). Hemodynamic and autonomic variables were measured at baseline, during, and immediately after tDCS or SHAM stimulation (Finometer®, Beatscope). Ambulatory BP measurement (ABPM) was evaluated after the experimental period. Results: Hemodynamic variables were not changed by tDCS, except for the fall in peripheral vascular resistance (Δ = −1696.51 ± 204.65 dyn.s/cm5). After the tDCS, sympathetic modulation was decreased (−61.47%), and vagal modulation was increased (+38.09%). Such acute autonomic changes may have evoked positive results observed in 24 hs-systolic blood pressure (Δ = −8.4 ± 6.2; P = .0022) and 24hs-diastolic blood pressure (Δ = −5.4 ± 4.2; P = .0010) in tDCS subjects compared with that in SHAM. Conclusion: These findings suggest that the tDCS could promote positive acute adjustments on cardiac autonomic control and reduced values on 24-hs BP of HTN patients. More than a proof-of-concept, these results may point out to the future, where brain stimulation (tDCS) can be used to HTN syndromes, such as refractory HTN.

Published
2021
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2. ACUTE TRANSCRANIAL DIRECT CURRENT STIMULATION (tDCS) IMPROVES VENTILATORY VARIABILITY AND AUTONOMIC MODULATION IN RESISTANT HYPERTENSIVE PATIENTS

Author

Gabriela Ministro, Javier B. Castaño, Catarina A. Barboza, Eliezer G. Moura, Silvia E. Ferreira-Melo, Cristiano T. Mostarda, André Fattori, Heitor Moreno-Junior, and Bruno Rodrigues

Subjects
Pulmonary and Respiratory Medicine, Male, Physiology, General Neuroscience, Blood Pressure, Middle Aged, Autonomic Nervous System, Transcranial Direct Current Stimulation, Cardiorespiratory Fitness, Hypertension, Exercise Test, Humans, Female, Pulmonary Ventilation, Aged
Abstract

Here, we assessed the impact of one session of transcranial direct current stimulation (tDCS) or SHAM (20 min, each) on ventilatory responses to cardiopulmonary exercise test, central and peripheral blood pressure (BP), and autonomic modulation in resistant hypertensive (RHT) patients. RHT subjects (n = 13) were randomly submitted to SHAM and tDCS crossing sessions (1 week of "washout"). Patients and a technician who set the tDCS/Sham room up were both blind. After brain stimulation, patients were submitted to a cardiopulmonary exercise test to evaluate ventilatory and cardiovascular response to exercise. Hemodynamic (Finometer®, Beatscope), and autonomic variables were measured at baseline (before tDCS/Sham) and after incremental exercise. RESULTS: Our study shows that tDCS condition improved heart rate recovery, VO2 peak, and vagal modulation (after cardiopulmonary exercise test); attenuated the ventilatory variability response, central and peripheral blood pressure well as sympathetic modulation (after cardiopulmonary exercise test) in comparison with SHAM. These data suggest that acute tDCS sessions prevented oscillatory ventilation behavior during the cardiopulmonary exercise test and mitigated the increase of systolic blood pressure in RHT patients. After the exercise test, tDCS promotes better vagal reentry and improved autonomic modulation, possibly reducing central blood pressure and aortic augmentation index compared to SHAM. Brazilian Registry of Clinical Trials (ReBEC): https://ensaiosclinicos.gov.br/rg/RBR-8n7c9p.

Published
2021

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