1. Hypoglycemia in a Patient with Hypercortisolism and Adrenocortical Carcinoma: A Paradoxical Entity.
- Author
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Khadka S, Mandal S, Kasireddy V, Ghimire S, Maganti T, and Mols-Kowalczewski B
- Subjects
- Humans, Prognosis, Adrenal Cortex Neoplasms complications, Adrenocortical Carcinoma complications, Adrenocortical Carcinoma diagnosis, Cushing Syndrome complications, Cushing Syndrome diagnosis, Hypoglycemia complications
- Abstract
Adrenal cortical carcinoma is a rare and aggressive cancer with poor prognosis. Cases usually present with signs and symptoms of excessive hormone production. Hyperglycemia and Cushing syndrome are common, but tumor-associated hypoglycemia due to paraneoplastic secretion of insulin-like growth factor-2 (termed Anderson's syndrome) is uncommon. Given the rarity of adrenal cortical carcinoma, diagnosis and management of associated complications is challenging. In this study, we present a case of metastatic adrenal cortical carcinoma with a myriad of hormonal abnormalities. We will also briefly review literature regarding genetic association, pathophysiology, treatment options, and prognosis.
- Published
- 2022
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