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Start Over Descriptor "glial cell derived neurotrophic factor (GDNF)" Topic hypoxia
1 results on '"glial cell derived neurotrophic factor (GDNF)"'

1. Antihypoxic and Neuroprotective Effects of Glial Cell-Derived Neurotrophic Factor (GDNF) in Cultures of Dissociated Hippocampal Cells under Conditions of Experimental Hypoxia.

Author

Vedunova, M., Shishkina, T., Mishchenko, T., Mitroshina, E., Astrakhanova, T., Pimashkin, A., and Mukhina, I.

Subjects
*NEUROPROTECTIVE agents, *GLIAL cell line-derived neurotrophic factor, *CELL culture, *HIPPOCAMPUS (Brain), *HYPOXEMIA
Abstract

We analyzed the effect of glial cell derived neurotrophic factor (GDNF) on changes in functional bioelectric and calcium activity in dissociated hippocampal cell cultures under conditions of modeled acute normobaric hypoxia in vitro. GDNF (1 ng/ml) partially neutralized the negative effects of hypoxia on cell survival and parameters of functional network activity. GDNF exhibited a pronounced anti-hypoxic effect. [ABSTRACT FROM AUTHOR]

Published
2016
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