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Your search keyword '"Dopamine D2 Receptor Antagonists chemistry"' showing total 2 results
Start Over Descriptor "Dopamine D2 Receptor Antagonists chemistry" Topic hypromellose derivatives
2 results on '"Dopamine D2 Receptor Antagonists chemistry"'

1. Formulation of instant disintegrating buccal films without using disintegrant: An in-vitro study.

Author

Zaman M, Hassan R, Amjad MW, Khan SM, Gaffor Raja MA, Shah SS, Siddique W, Aman W, Abid Z, and Butt MH

Subjects
Administration, Buccal, Dopamine D2 Receptor Antagonists administration & dosage, Dosage Forms, Drug Compounding, Drug Liberation, Kinetics, Metoclopramide administration & dosage, Serotonin 5-HT1 Receptor Agonists administration & dosage, Solubility, Spectrophotometry, Ultraviolet, Sumatriptan administration & dosage, Tensile Strength, Dopamine D2 Receptor Antagonists chemistry, Glycerol chemistry, Hypromellose Derivatives chemistry, Metoclopramide chemistry, Serotonin 5-HT1 Receptor Agonists chemistry, Sumatriptan chemistry
Abstract

The current study was conducted to fabricate Metoclopramide HCL (MCH) and Sumatriptan succinate (SS) instant release buccal films (IRBF) without using any super disintegrant. The solvent casting method was used for the preparation of IRBFs and prepared IRBFs were physicochemically evaluated. Spectrophotometric analysis was done to determine the lambda max followed by the linearity determination of both drugs. Different concentrations such as 100, 125, and 150mg of hydrophilic polymer (HPMC E5) were employed but the concentration of glycerol was variable. Comparatively better results were observed for the formulation with 150mg of HPMC E5 and 30% glycerol. Formulated IRBFs showed good tensile strength with a mean disintegration time of 12.4-28.4 seconds and rapid dissolution with more than 50% drug release within 2 minutes. It was concluded that the chosen combination of polymers was appropriate for the fabrication of MCH and SS buccal strips.

Published
2021

2. Controlled release effervescent buccal discs of buspirone hydrochloride: in vitro and in vivo evaluation studies.

Author

Jaipal A, Pandey MM, Charde SY, Sadhu N, Srinivas A, and Prasad RG

Subjects
Adhesiveness, Administration, Buccal, Animals, Biological Availability, Buspirone chemistry, Carbon Dioxide chemistry, Citric Acid chemistry, Delayed-Action Preparations, Dopamine D2 Receptor Antagonists chemistry, Dosage Forms, Drug Compounding, Gases, Male, Mouth Mucosa metabolism, Oral Mucosal Absorption, Permeability, Rabbits, Serotonin Receptor Agonists chemistry, Sodium Bicarbonate chemistry, Solubility, Technology, Pharmaceutical methods, Buspirone administration & dosage, Buspirone pharmacokinetics, Dopamine D2 Receptor Antagonists administration & dosage, Dopamine D2 Receptor Antagonists pharmacokinetics, Drug Carriers, Hypromellose Derivatives chemistry, Serotonin Receptor Agonists administration & dosage, Serotonin Receptor Agonists pharmacokinetics
Abstract

In the present study controlled release effervescent buccal discs of buspirone hydrochloride (BS) were designed using HPMC as rate controlling and bioadhesive polymer by direct compression method. Sodium bicarbonate and citric acid were used in varying amounts as effervescence forming agents. Carbon dioxide evolved due to reaction of sodium bicarbonate and citric acid was explored for its potential as buccal permeation enhancer. The designed buccal discs were evaluated for physical characteristics and in vitro drug release studies. Bioadhesive behavior of designed buccal discs was assessed using texture analyzer. In vivo animal studies were performed in rabbits to study bioavailability of BS in the designed buccal discs and to establish permeation enhancement ability of carbon dioxide. It was observed that effervescent buccal discs have faster drug release compared to non-effervescent buccal discs in vitro and effervescent buccal discs demonstrated significant increase in bioavailability of drug when compared to non-effervescent formulation. Hence, effervescent buccal discs can be used as an alternative to improve the drug permeation resulting in better bioavailability. However, the amount of acid and base used for generation of carbon dioxide should be selected with care as this may damage the integrity of bioadhesive dosage form.

Published
2016
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