Search

Objective: Granulosa cell tumor (GCT) of the ovary is an uncommon neoplasm with good prognosis. GCT is a rare ovarian malignancy originating from sex cord-stromal cells. The only clinically proven prognostic factor regarding recurrence is stage. In this study, we aimed to analyze the detailed clinical and histopathological prognostic parameters of this rare malignancy, based on the cases we experienced in our own clinic. Material and Methods: Forty-six patients who were followed up and treated with the diagnosis of granulosa cell ovarian tumor between 2010 and 2020 were evaluated retrospectively by scanning the patient archive files. Results: The median follow-up period was 52 months. The mean patient age was 55 years. The most common symptom was abdominal pain. The most common surgical procedure was total abdominal hysterectomy+bilateral salpingo-oophorectomy+pelvic/paraaortic lymph node dissection with 60.9% (n=28). Fertility sparing surgery was performed for 5 (10.9%) patients. In this study, a significant relationship was found between the survival and FIGO stage, nuclear atypia, mitotic rate. The rate of metastatic lymph nodes is very low in primary surgery and therefore may not be performed. Conclusion: GCT is one of the rare diseases of ovary. Since recurrence may occur even after many years, the follow-up period should be kept long. Stage is still the most important prognostic factor and is directly related to survival. In addition, the mitotic rate and nuclear atypia of the tumor may also be prognostic factors and have an impact on survival. [ABSTRACT FROM AUTHOR]

Objective: This study aimed to evaluate the significance and correlation of immunohistochemical staining of lumican, an extracellular matrix proteoglycan, with the clinicopathological parameters in endometrial intraepithelial neoplasia (EIN) and endometrioid-type endometrial cancer (ETEC). Material and Methods: This cross-sectional study was carried out together in the obstetrics & gynecology and pathology departments of a tertiary care center. A total of 46 patients with EIN (n=19; 41.3%) and ETEC (n=27; 58.7%) were recruited for the study. Sections prepared from hysterectomy specimens of the patients were immunohistochemically processed and examined for immunohistochemical staining of lumican. The positive association between immunohistochemical staining of lumican and its relationship with clinicopathological variables were then investigated. Results: Lumican staining was more prominent in specimens obtained from ETEC patients as compared to that obtained from patients with EIN. The patients in the ETEC group were significantly elder than those in the EIN group. No statistically significant association was found between the lumican positivity and the histopathological parameters including grade; stage; squamous differentiation; lymph node metastases; myometrial, cervical, adnexial or omental invasion; and pelvic or paraaortic lymph node involvement. Conclusion: The study concluded that elucidation of the molecular basis underlying endometrial cancer may allow the recognition of novel molecular targets for diagnostic and therapeutic strategies of cancers of the endometrium. However, the importance of immunohistochemical staining and clinicopathological significance of lumican in endometrial cancer needs to be further studied by multicentric studies in larger numbers. [ABSTRACT FROM AUTHOR]