Author: "Trofimova ES" / Topic: i-kappa b kinase - Searchworks@Jio Institute Digital Library Search Results

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Start Over Author "Trofimova ES" Topic i-kappa b kinase

Author: Zyuz'kov GN, Zhdanov VV, Danilets MG, Udut EV, Miroshnichenko LA, Ligacheva AA, Simanina EV, Chaikovskii AV, Trofimova ES, Minakova MY, Udut VV, and Dygai AM
Subjects: Animals, Cells, Cultured, Mesenchymal Stem Cells cytology, Mice, Regenerative Medicine, Cyclic AMP metabolism, Fibroblast Growth Factor 2 pharmacology, I-kappa B Kinase metabolism, Mesenchymal Stem Cells drug effects, Mesenchymal Stem Cells metabolism, Signal Transduction physiology
Abstract: We studied the role of cAMP- and IKK-2-dependent pathways under conditions of functional stimulation of mesenchymal progenitor cells by basic fibroblast growth factor. An adenylate cyclase inhibitor 2',5'-dideoxyadenosine had no effect on functional activity of early (primitive) mesenchymal precursors. This agent produced a stimulatory effect on proliferation of stromal precursor cells. Mitotic activity of mesenchymal progenitor cells was shown to decrease after treatment with a specific blocker of the IKK-2 kinase-inhibitor complex.
Published: 2014
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Author: Zyuz'kov GN, Zhdanov VV, Danilets MG, Udut EV, Miroshnichenko LA, Ligacheva AA, Simanina EV, Trofimova ES, Minakova MY, Chaikovskii AV, and Dygai AM
Subjects: Adenylyl Cyclase Inhibitors, Animals, Bone Marrow Cells metabolism, Cell Differentiation drug effects, Cell Proliferation drug effects, Cells, Cultured, Colony-Forming Units Assay, Cyclic AMP metabolism, Fibroblasts drug effects, I-kappa B Kinase antagonists & inhibitors, Male, Mice, Mice, Inbred CBA, Signal Transduction drug effects, Adenylyl Cyclases metabolism, Dideoxyadenosine pharmacology, Hematopoietic Stem Cells metabolism, I-kappa B Kinase metabolism, Mesenchymal Stem Cells physiology
Abstract: We studied the role of cAMP- and IKK-2-mediated pathways in the realization of growth potential of mesenchymal progenitor cells in vitro. It had been found that adenylate cyclase inhibitor 2',5'-dideoxyadenosine had no effect on the proliferation and differentiation of fibroblastic CFU. A decrease in differentiation rate of progenitor cells was observed after the treatment with specific IKK-2 blocker inhibitor-kinase complex.
Published: 2013
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Author: Ligacheva AA, Ivanova AN, Belsky YP, Belska NV, Trofimova ES, Danilets MG, and Dygai AM
Subjects: Animals, Anti-Inflammatory Agents, Non-Steroidal pharmacology, Edema drug therapy, Female, Hypersensitivity, Delayed immunology, Hypersensitivity, Immediate immunology, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, NF-kappa B metabolism, Th1 Cells drug effects, Th2 Cells drug effects, Diclofenac pharmacology, Hypersensitivity, Delayed drug therapy, Hypersensitivity, Immediate drug therapy, I-kappa B Kinase antagonists & inhibitors, Phenylurea Compounds pharmacology, Th1 Cells immunology, Th2 Cells immunology, Thiophenes pharmacology
Abstract: We studied the capacity of IKK-2 inhibitor ([5-(p-fluorophenyl)-2-ureido] thiophene-3-carboxamide) and non-steroidal anti-inflammatory drug voltaren to reduce the severity of local inflammation in Th1- and Th2-type immune response. The test substances (inhibitor in concentrations from 2×10(-13)to 2×10(-16)M and 9.8×10(-4)M voltaren) were shown to reduce edema caused by sheep erythrocytes (Th1-type immune response) and local immediate-type hypersensitivity response (Th2-type immune response). The anti-inflammatory effects of IKK-2 inhibitor in Th1-type immune response were similar to those of voltaren.
Published: 2013
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