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Objective: To investigate the effect of Vitamin D combined with anti tuberculosis drugs on the serum levels of IL-1 and interferon gamma of elderly patients with spinal tuberculosis. Methods: 96 elderly patients with spinal tuberculosis in our hospital from July 2014 to July 2016 were selected and randomly divided into the control group and the experiment group, with 48 cases in each group. The control group was treated by regular anti tuberculosis treatment and the experiment group was treated on the base of the control group with VitaminD Drops. 8 weeks for a course of treatment, a total of a course of treatment. The VAS score, degree of spinal cord injury, serum levels of IL-1 and interferon gamma were compared between two groups after treatment. Compared with before treatment, the VAS scores of two groups were lower after treatment (P<0.05), the degrees of spinal cord injury were less (P<0.05), the serum IL-1βand IFN-γlevels were lower (P<0.05). Results: Compared with the control group, the VAS score was lower the in the experiment group (P<0.05), the degree of spinal cord injury was less (P<0.05), the serum IL-1βand IFN-γlevels were lower (P<0.05). Conclusion: Vitamin D combined with anti tuberculosis drugs could significantly reduce the pain and the degree of spinal cord injury in elderly patients with spinal tuberculosis, which might be related to the decrease of serumIL-1 beta and interferon gamma levels. [ABSTRACT FROM AUTHOR]

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