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Your search keyword '"Moreau, Mathieu"' showing total 5 results
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5 results on '"Moreau, Mathieu"'

1. Innovative Magnetic Nanoparticles for PET/MRI Bimodal Imaging

Author

Thomas, Guillaume, Boudon, Julien, Maurizi, Lionel, Moreau, Mathieu, Walker, Paul, Séverin, Isabelle, Oudot, Alexandra, Goze, Christine, Poty, Sophie, Vrigneaud, Jean-Marc, Demoisson, Frédéric, Denat, Franck, Brunotte, François, Millot, Nadine, Laboratoire Interdisciplinaire Carnot de Bourgogne [Dijon] (LICB), Université de Bourgogne (UB)-Université de Technologie de Belfort-Montbeliard (UTBM)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon] (ICMUB), Centre National de la Recherche Scientifique (CNRS)-Université de Bourgogne (UB)-Institut de Chimie du CNRS (INC), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Equipe NuTox (LNC - U1231) (NUTOX), Lipides - Nutrition - Cancer [Dijon - U1231] (LNC), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Santé et de la Recherche Médicale (INSERM), Plateforme d'imagerie préclinique [Centre Georges-François Leclerc] (CGFL), Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER-UNICANCER, Laboratoire Interdisciplinaire Carnot de Bourgogne (ICB), Université de Technologie de Belfort-Montbeliard (UTBM)-Université de Bourgogne (UB)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS), Université de Bourgogne (UB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, and Dijon, Institut Agro

Subjects
lcsh:Chemistry, [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, lcsh:QD1-999, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, technology, industry, and agriculture, Nanoparticles, Imaging agents, Tomography, Article, [SDV.BIO] Life Sciences [q-bio]/Biotechnology, Nanostructures
Abstract

International audience; Superparamagnetic iron oxide nanoparticles were developed as positron emission tomography (PET) and magnetic resonance imaging (MRI) bimodal imaging agents. These nanoparticles (NPs), with a specific nanoflower morphology, were first synthesized and simultaneously functionalized with 3,4-dihydroxy-l-phenylalanine (LDOPA) under continuous hydrothermal conditions. The resulting NPs exhibited a low hydrodynamic size of 90 ± 2 nm. The functional groups of LDOPA (-NH2 and -COOH) were successfully used for the grafting of molecules of interest in a second step. The nanostructures were modified by poly(ethylene glycol) (PEG) and a new macrocyclic chelator MANOTA for further ⁶⁴Cu radiolabeling for PET imaging. The functionalized NPs showed promising bimodal (PET and MRI) imaging capability with high r2 and r2∗ (T2 and T2∗ relaxivities) values and good stability. They were mainly uptaken from liver and kidneys. No cytotoxicity effect was observed. These NPs appear as a good candidate for bimodal tracers in PET/MRI.

Published
2019

2. BODIPY: A Highly Versatile Platform for the Design of Bimodal Imaging Probes.

Author

Lhenry, Damien, Larrouy, Manuel, Bernhard, Claire, Goncalves, Victor, Raguin, Olivier, Provent, Peggy, Moreau, Mathieu, Collin, Bertrand, Oudot, Alexandra, Vrigneaud, Jean ‐ Marc, Brunotte, François, Goze, Christine, and Denat, Franck

Subjects
OPTICAL imaging sensors, MOLECULAR probes, FLUORESCENT dyes, CYCLIC peptides, BIOCONJUGATES, RADIOLABELING
Abstract

In molecular imaging, multimodal imaging agents can provide complementary information, for improving the accuracy of disease diagnosis or enhancing patient management. In particular, optical/nuclear imaging may find important preclinical and clinical applications. To simplify the preparation of dual-labeled imaging agents, we prepared versatile monomolecular multimodal imaging probe (MOMIP) platforms containing both a fluorescent dye (BODIPY) and a metal chelator (polyazamacrocycle). One of the MOMIP was conjugated to a cyclopeptide (i.e., octreotide) and radiolabeled with 111In. In vitro and in vivo studies of the resulting bioconjugate were conducted, highlighting the potential of these BODIPY-based bimodal probes. This work also confirmed that the biovector and/or the bimodal probes must be chosen carefully, due to the impact of the MOMIP on the overall properties of the resulting imaging agent. [ABSTRACT FROM AUTHOR]

Published
2015
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3. Highly Fluorescent and Water-Soluble Diketopyrrolopyrrole Dyes for Bioconjugation.

Author

Heyer, Elodie, Lory, Pauline, Leprince, Jérôme, Moreau, Mathieu, Romieu, Anthony, Guardigli, Massimo, Roda, Aldo, and Ziessel, Raymond

Subjects
DYES & dyeing, HYDROPHILIC compounds, CARBOXYLIC acids, FLUORESCENCE yield, DETECTION limit
Abstract

The preparation of highly water-soluble and strongly fluorescent diketopyrrolopyrrole (DPP) dyes using an unusual taurine-like sulfonated linker has been achieved. Exchanging a phenyl for a thienyl substituent shifts the emission wavelength to near λ=600 nm. The free carboxylic acid group present in these new derivatives was readily activated and the dyes were subsequently covalently linked to a model protein (bovine serum albumin; BSA). The bioconjugates were characterized by electronic absorption, fluorescence spectroscopy and MALDI-TOF mass spectrometry, thus enabling precise determination of the labeling density (ratio DPP/BSA about 3 to 8). Outstanding values of fluorescence quantum yield (30 % to 59 %) for these bioconjugates are obtained. The photostability of these DPP dyes is considerably greater than that of fluorescein under the same irradiation conditions. Remarkably low detection limits between 80 and 300 molecules/μm2 were found for the BSA bioconjugates by fluorescence imaging with a epifluorescence microscope. [ABSTRACT FROM AUTHOR]

Published
2015
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4. DOTAGA-Anhydride: A Valuable Building Block for the Preparation of DOTA-Like Chelating Agents.

Author

Bernhard, Claire, Moreau, Mathieu, Lhenry, Damien, Goze, Christine, Boschetti, Frédéric, Rousselin, Yoann, Brunotte, François, and Denat, Franck

Abstract

A DOTA derivative that contains an anhydride group was readily synthesized by reacting DOTAGA with acetic anhydride and its reactivity was investigated. Opening the anhydride with propylamine led to the selective formation of one of two possible regioisomers. The structure of the obtained isomer was unambiguously determined by 1D and 2D NMR experiments, including COSY, HMBC, and NOESY techniques. This bifunctional chelating agent offers a convenient and attractive approach for labeling biomolecules and, more generally, for the synthesis of a large range of DOTA derivatives. The scope of the reaction was extended to prepare DOTA-like compounds that contained various functional groups, such as isothiocyanate, thiol, ester, and amino acid moieties. This versatile building block was also used for the synthesis of a bimodal tag for SPECT or PET/optical imaging. [ABSTRACT FROM AUTHOR]

Published
2012
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5. Highly Fluorescent and Water-Soluble Diketopyrrolopyrrole Dyes for Bioconjugation

Author

Elodie Heyer, Pauline Lory, Anthony Romieu, Massimo Guardigli, Aldo Roda, Raymond Ziessel, Jérôme Leprince, Mathieu Moreau, Heyer, Elodie, Lory, Pauline, Leprince, Jérôme, Moreau, Mathieu, Romieu, Anthony, Guardigli, Massimo, Roda, Aldo, Ziessel, Raymond, Institut de chimie et procédés pour l'énergie, l'environnement et la santé (ICPEES), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Neuroendocrinologie cellulaire et moléculaire, Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Différenciation et communication neuronale et neuroendocrine (DC2N), Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon] (ICMUB), Université de Bourgogne (UB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des Matériaux, Surfaces et Procédés pour la Catalyse (LMSPC), and Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et nanosciences d'Alsace (FMNGE)

Subjects
Carboxylic acid, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Fluorescent Dye, Quantum yield, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, 010402 general chemistry, Photochemistry, Pyrrole, 01 natural sciences, Fluorescence spectroscopy, Fluorescence, Catalysis, chemistry.chemical_compound, [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], Fluorescence microscope, MESH: Water, Organic chemistry, Pyrroles, Fluorescein, Bovine serum albumin, Fluorescent Dyes, chemistry.chemical_classification, Bioconjugation, biology, 010405 organic chemistry, Synthetic method, Protein, Chemistry (all), Dyes/pigment, Water, General Chemistry, General Medicine, MESH: Fluorescent Dyes, proteins, 0104 chemical sciences, imaging agents, MESH: Solubility, chemistry, Solubility, biology.protein, synthetic methods, MESH: Pyrroles, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, dyes/pigments, Imaging agent
Abstract

International audience; The preparation of highly water-soluble and strongly fluorescent diketopyrrolopyrrole (DPP) dyes using an unusual taurine-like sulfonated linker has been achieved. Exchanging a phenyl for a thienyl substituent shifts the emission wavelength to near λ=600 nm. The free carboxylic acid group present in these new derivatives was readily activated and the dyes were subsequently covalently linked to a model protein (bovine serum albumin; BSA). The bioconjugates were characterized by electronic absorption, fluorescence spectroscopy and MALDI-TOF mass spectrometry, thus enabling precise determination of the labeling density (ratio DPP/BSA about 3 to 8). Outstanding values of fluorescence quantum yield (30% to 59%) for these bioconjugates are obtained. The photostability of these DPP dyes is considerably greater than that of fluorescein under the same irradiation conditions. Remarkably low detection limits between 80 and 300 molecules/μm(2) were found for the BSA bioconjugates by fluorescence imaging with a epifluorescence microscope.

Published
2015

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