1. Tuberculosis in a Spanish cohort of children living with HIV: the CHOTIS study (Childhood HIV & TB study)
- Author
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Lopez-Medina, EM, Sainz, T, de Ory, SJ, Mellado-Pena, MJ, Gonzalez-Tome, MI, Gil, EC, Cucurull, TV, Neyra, F, Frick, MA, Martinez-Perez, J, Andres, AGA, Alonso, MB, Laleona, CG, Hernandez, MM, Hernandez, PC, Amador, JTR, Gomez, MLN, and Santiago-Garcia, B
- Subjects
co-infection ,tuberculosis ,HIV ,cART ,immigration - Abstract
BACKGROUND: Tuberculosis (TB) is the leading opportunistic infection in children with human immunodeficiency virus (HIV), but is uncommon in low prevalence regions. We aim to describe the changing epidemiology and clinical presentation of TB-HIV co infection in a cohort of HIV-infected children in Spain. METHODS: Children diagnosed with TB between 1995 and 2016 in the paediatric HIV cohort were identified. The incidence and clinical presentation were compared in three periods: 1995-1999 (P1, before initiation of combined antiretroviral therapy, cART), 2000-2009 (P2, increase in immigration), and 2010-2016 (P3, decrease in immigration). RESULTS: We included 29 TB cases among 1183 children aged ,18 years (2.4%, 243/100 000 person years). The proportion was stable in P1 and P2 (1.3%), but decreased in P3 (0.8%). The median age at TB diagnosis was 6.4 years (IQR 4-10.6); most children in P3 were aged .10 years (20% vs. 23.1% vs. 83.3%, P = 0.01). TB was diagnosed at HIV presentation in 11/29 children (37.9%). Foreign-born children accounted for respectively 0%, 8% and 67% of the total number of children in each period (P
- Published
- 2020