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Your search keyword '"Gong, Siming"' showing total 3 results
Start Over Author "Gong, Siming" Topic immune checkpoint proteins
3 results on '"Gong, Siming"'

1. Integrative and Comprehensive Pancancer Analysis of Regulator of Chromatin Condensation 1 (RCC1)

Author

Wu, Changwu, Duan, Yingjuan, Gong, Siming, Kallendrusch, Sonja, Schopow, Nikolas, and Osterhoff, Georg

Subjects
tumor, Carcinogenesis, QH301-705.5, Cell Cycle Proteins, Kaplan-Meier Estimate, CD8-Positive T-Lymphocytes, Article, enrichment analysis, Cancer-Associated Fibroblasts, big data, Neoplasms, Databases, Genetic, Guanine Nucleotide Exchange Factors, Humans, Protein Interaction Maps, Phosphorylation, Biology (General), QD1-999, immune infiltration, Cell Cycle, Nuclear Proteins, pancancer, DNA Methylation, Immune Checkpoint Proteins, Chromatin, Gene Expression Regulation, Neoplastic, RCC1, Chemistry, Gene Ontology, Microsatellite Instability, prognosis, Transcriptome
Abstract

Regulator of Chromatin Condensation 1 (RCC1) is the only known guanine nucleotide exchange factor that acts on the Ras-like G protein Ran and plays a key role in cell cycle regulation. Although there is growing evidence to support the relationship between RCC1 and cancer, detailed pancancer analyses have not yet been performed. In this genome database study, based on The Cancer Genome Atlas, Genotype-Tissue Expression and Gene Expression Omnibus databases, the potential role of RCC1 in 33 tumors’ entities was explored. The results show that RCC1 is highly expressed in most human malignant neoplasms in contrast to healthy tissues. RCC1 expression is closely related to the prognosis of a broad variety of tumor patients. Enrichment analysis showed that some tumor-related pathways such as “cell cycle” and “RNA transport” were involved in the functional mechanism of RCC1. In particular, the conducted analysis reveals the relation of RCC1 to multiple immune checkpoint genes and suggests that the regulation of RCC1 is closely related to tumor infiltration of cancer-associated fibroblasts and CD8+ T cells. Coherent data demonstrate the association of RCC1 with the tumor mutation burden and microsatellite instability in various tumors. These findings provide new insights into the role of RCC1 in oncogenesis and tumor immunology in various tumors and indicate its potential as marker for therapy prognosis and targeted treatment strategies.

Published
2021

2. An Integrative Pan-Cancer Analysis of Kinesin Family Member C1 (KIFC1) in Human Tumors.

Author

Wu, Hao, Duan, Yingjuan, Gong, Siming, Zhu, Qiang, Liu, Xuanyou, and Liu, Zhenguo

Subjects
KINESIN, MYELOID-derived suppressor cells, MOLECULAR motor proteins, IMMUNE checkpoint proteins, STATISTICAL correlation, HUMAN carcinogenesis, SUPERNUMERARY teeth
Abstract

Kinesin family member C1 (KIFC1) is a minus-end-directed motor protein that is critically involved in microtubule crosslinking and spindle formation. KIFC1 is essential for supernumerary centrosomes, and it is associated with the initiation and progression of cancers. In the present study, we initially reviewed the The Cancer Genome Atlas database and observed that KIFC1 is abundantly expressed in most types of tumors. We then analyzed the gene alteration profiles, protein expressions, prognoses, and immune reactivities of KIFC1 in more than 10,000 samples from several well-established databases. In addition, we conducted a gene set enrichment analysis to investigate the potential mechanisms for the roles of KIFC1 in carcinogenesis. The pan-cancer analysis of KIFC1 demonstrates significant statistical correlations of the KIFC1 expression with the clinical prognoses, the oncogenic signature gene sets, the myeloid-derived suppressor cell infiltration, the ImmunoScore, the immune checkpoints, the microsatellite instabilities, and the tumor mutational burdens across multiple tumors. These data may provide important information on the understanding of the role and mechanisms of KIFC1 in carcinogenesis and immunotherapy, as well as on the clinical progression of a variety of cancers. [ABSTRACT FROM AUTHOR]

Published
2022
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3. A Comprehensive Pan-Cancer Analysis for Pituitary Tumor-Transforming Gene 1.

Author

Gong, Siming, Wu, Changwu, Duan, Yingjuan, Tang, Juyu, and Wu, Panfeng

Subjects
IMMUNE checkpoint proteins, GENES, TUMOR treatment, MICROSATELLITE repeats
Abstract

Pituitary tumor-transforming gene 1 (PTTG1) encodes a multifunctional protein that is involved in many cellular processes. However, the potential role of PTTG1 in tumor formation and its prognostic function in human pan-cancer is still unknown. The analysis of gene alteration, PTTG1 expression, prognostic function, and PTTG1-related immune analysis in 33 types of tumors was performed based on various databases such as The Cancer Genome Atlas database, the Genotype-Tissue Expression database, and the Human Protein Atlas database. Additionally, PTTG1-related gene enrichment analysis was performed to investigate the potential relationship and possible molecular mechanisms between PTTG1 and tumors. Overexpression of PTTG1 may lead to tumor formation and poor prognosis in various tumors. Consequently, PTTG1 acts as a potential oncogene in most tumors. Additionally, PTTG1 is related to immune infiltration, immune checkpoints, tumor mutational burden, and microsatellite instability. Thus, PTTG1 could be potential biomarker for both prognosis and outcomes of tumor treatment and it could also be a promising target in tumor therapy. [ABSTRACT FROM AUTHOR]

Published
2022
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