1. Immune-metabolic interactions between Leishmania and macrophage host.
- Author
-
Ferreira, Carolina, Estaquier, Jérôme, and Silvestre, Ricardo
- Subjects
- *
LEISHMANIASIS , *AMINO acid metabolism , *LEISHMANIA , *MACROPHAGES , *IMMUNE response - Abstract
• Host AMPK, mTOR and HIF-1α are key regulators of Leishmania infection. • Leishmania hijacks amino acid metabolism to proliferate inside the host. • Modulation of host metabolism represents an attractive target for leishmaniasis. Manipulation of host metabolic fluxes by Leishmania represents a strategy to circumvent host immune response leading to long-term parasite survival and playing an important role in the pathology of infection. Specific Leishmania -dependent metabolic alterations in infected macrophages have been associated with resistance or susceptibility to infection. Thus, deciphering the multilevel interactions between metabolism and function on innate immune cells during infection offers considerable therapeutic or prophylactic promise. In this review, we provide an overview of recent literature highlighting Leishmania- macrophage interactions and discuss the potential of metabolic targeted therapies to shift the balance of dysfunctional, damaging, or non-productive responses to protective immune reactivity patterns towards pathogen elimination. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF