1. [Immunotropic properties of anaferon and anaferon pediatric].
- Author
-
Zhavbert ES, Dugina IuL, and Épshteĭn OI
- Subjects
- Adult, Animals, B-Lymphocytes cytology, B-Lymphocytes drug effects, B-Lymphocytes immunology, Child, Female, Humans, Interferon-gamma antagonists & inhibitors, Interferon-gamma immunology, Killer Cells, Natural cytology, Killer Cells, Natural drug effects, Killer Cells, Natural immunology, Macrophages cytology, Macrophages drug effects, Macrophages immunology, Male, Mice, Mice, Inbred CBA, Neutrophils cytology, Neutrophils drug effects, Neutrophils immunology, T-Lymphocytes cytology, T-Lymphocytes drug effects, T-Lymphocytes immunology, Antibodies pharmacology, Antiviral Agents pharmacology, Immunity, Cellular drug effects, Immunity, Humoral drug effects, Immunity, Innate drug effects, Interferon Inducers pharmacology
- Abstract
Anaferon and pediatric anaferon based on release-active antibodies to interferon-gamma (R-A antibodies to INF-gamma) proved to be efficient in the treatment of many viral infections. Immunomodulating (immunotropic) properties of the drugs were revealed in the preclinical studies at many Russian and foreign research medical institutions and are reviewed herein. Anaferon and pediatric anaferon stimulated the humoral and cellular immune responses and increased the neutrophil and macrophage activity. The crucial mechanism of the immunotropic action of R-A antibodies to INF-gamma was the effect on the system of interferons and in particular on INF-gamma and functionally conjugated cytokines, resulting in normalization of the functional activity of the innate factors of the immune defense and increasing of the antiviral action. The broad spectrum of the immunotropic activity provided the success of anaferon and anaferon pediatric for more than 10 years in the treatment and prophylaxis of the diseases associated with disorders in the immune system functional state.
- Published
- 2013