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Oncological patients requiring parenteral nutrition (PN) will often be at risk of excessive inflammatory responses and immunosuppression. Traditionally used in artificial nutrition soybean oil (rich in omega-6 fatty acids) could promote inflammation and immunosuppression. Parenteral administration of fish oil has been demonstrated to modify the fatty acids (FA) composition of plasma lipids, cells and tissues. increased content of omega-3 FA in cell membranes can influence cell function through various mechanisms: alteration fluidity of the cell membrane, effects on cell signaling pathways and gene expression, alterations in the pattern of lipid mediators produced e.g. eicosanoids. [ABSTRACT FROM AUTHOR]

Oncological patients requiring parenteral nutrition (PN) will often be at risk of excessive inflammatory responses and immunosuppression. Traditionally used in artificial nutrition soybean oil (rich in omega-6 fatty acids) could promote inflammation and immunosuppression. Parenteral administration of fish oil has been demonstrated to modify the fatty acids (FA) composition of plasma lipids, cells and tissues. Increased content of omega-3 FA in cell membranes can influence cell function through various mechanisms: alteration fluidity of the cell membrane, effects on cell signaling pathways and gene expression, alterations in the pattern of lipid mediators produced e.g. eicosanoids. [ABSTRACT FROM AUTHOR]