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Start Over Author "E. Witwicki" Topic immunoenzyme techniques
2 results on '"E. Witwicki"'

1. Serum aminoglycoside monitoring by enzyme immunoassay, biological, and fluorescence immunoassay procedures.

Author

Buchanan AG, Witwicki E, and Albritton WL

Subjects
Aminoglycosides blood, Costs and Cost Analysis, Evaluation Studies as Topic, Gentamicins blood, Humans, Tobramycin blood, Anti-Bacterial Agents blood, Biological Assay economics, Fluorescent Antibody Technique economics, Immunoenzyme Techniques economics
Abstract

Aerobic gram-negative infections are treated with aminoglycosides, but it is difficult to achieve safe yet effective dosages in individual patients using a standard dosing formula. Serum aminoglycoside levels are monitored to determine dosage adjustments. We compared enzyme immunoassay, bioassay, and fluorescence immunoassay procedures for measuring gentamicin and tobramycin levels in patients' sera, and in pooled human sera containing added gentamicin and tobramycin. The enzyme immunoassay procedure provided the most acceptable method for monitoring serum aminoglycoside levels on the bases of precision, cost, and turnaround time.

Published
1983

2. Serum aminoglycoside monitoring by enzyme immunoassay, biological, and fluorescence immunoassay procedures

Author

A G, Buchanan, E, Witwicki, and W L, Albritton

Subjects
Immunoenzyme Techniques, Aminoglycosides, Evaluation Studies as Topic, Costs and Cost Analysis, Tobramycin, Fluorescent Antibody Technique, Humans, Biological Assay, Gentamicins, Anti-Bacterial Agents
Abstract

Aerobic gram-negative infections are treated with aminoglycosides, but it is difficult to achieve safe yet effective dosages in individual patients using a standard dosing formula. Serum aminoglycoside levels are monitored to determine dosage adjustments. We compared enzyme immunoassay, bioassay, and fluorescence immunoassay procedures for measuring gentamicin and tobramycin levels in patients' sera, and in pooled human sera containing added gentamicin and tobramycin. The enzyme immunoassay procedure provided the most acceptable method for monitoring serum aminoglycoside levels on the bases of precision, cost, and turnaround time.

Published
1983

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