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The study of the post-vaccine immune response and its relation to the IgG subclasses is a relatively new field in clinical immunology. Changes in IgG antibodies to vaccine antigens are an important criterion in the diagnosis of primary immunodeficiencies, such as Common variable immune deficiency (CVID), transient hypogammaglobulinemia in early childhood, selective IgA deficiency, or IgG subclass deficiency. On the other hand, the specific antibody deficiency (SAD), which is characterized by normal levels of immunoglobulins G, M, A and IgG subclasses, but with an abnormal antibody response to polysaccharide antigens after vaccination, is clinically manifested by recurrent respiratory infections. Globally, invasive pneumococcal diseases (otitis, pneumonia, meningitis, sepsis) cause over 800,000 deaths annually in children under 5 years of age, most of them due to pneumonia. This has raised interest in the clinical relevance of IgG subclass deficits and the level of protective immune response to polysaccharide antigens at different age groups and related vaccine programs. Therefore, we will present here the recommended vaccination strategies for patients with primary immunodeficiency. [ABSTRACT FROM AUTHOR]