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Your search keyword '"Shouliang Cai"' showing total 3 results
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3 results on '"Shouliang Cai"'

1. POU5F1/Oct-4 expression in breast cancer tissue is significantly associated with non-sentinel lymph node metastasis

Author

Feng Jin, Bo Chen, Shouliang Cai, Shugang Geng, Jisheng Liu, and Chang Qu

Subjects
0301 basic medicine, CA15-3, Oncology, Cancer Research, Pathology, genetic structures, Gene Expression, SLN, Metastasis, Breast cancer, 0302 clinical medicine, Surgical oncology, Odds Ratio, Lymph node, Aged, 80 and over, Middle Aged, Immunohistochemistry, medicine.anatomical_structure, Lymphatic Metastasis, 030220 oncology & carcinogenesis, Female, Research Article, Adult, medicine.medical_specialty, Sentinel lymph node, Breast Neoplasms, Non-SLN, Octamer binding factor, 03 medical and health sciences, Internal medicine, Biomarkers, Tumor, Genetics, medicine, Humans, Aged, Neoplasm Staging, Retrospective Studies, business.industry, Cancer, Nomogram, medicine.disease, eye diseases, MSKCC nomogram, 030104 developmental biology, ROC Curve, Neoplasm Grading, business, Octamer Transcription Factor-3
Abstract

Background At present, few studies have explored the significance of POU5F1 (also known as octamer-bingding factor, Oct-4 or Oct-3) expression in breast cancer tissues. Methods A total of 121 patients were retrospectively selected between May 2010 and March 2013 to investigate the relationship between POU5F1/Oct-4 expression in breast cancer tissues and non-sentinel lymph node (non-SLN) metastases and to validate the Memorial Sloan-Kettering Cancer Center (MSKCC) nomogram. All patients had early-stage breast cancer, which was histologically confirmed by the Department of Surgical Oncology, The First Affiliated Hospital of China Medical University. Histological type and grade of tumors were determined from tissue samples by hematoxylin and eosin staining, while the presence of POU5F1/Oct-4 protein was determined by immunohistochemistry. POU5F1/Oct-4 expression levels in tissues obtained from patients with sentinel lymph node (SLN) and non-SLN metastasis and in tissues obtained from patients without lymph node metastases were compared. Results POU5F1/Oct-4 expression levels in breast cancer tissues were significantly higher in both the SLN metastasis and non-SLN metastasis groups (P = 0.003 and P = 0.030, respectively). Furthermore, POU5F1/Oct-4 expression was found to be associated to both histological (P = 0.01) and molecular type (P = 0.03). Thus, our data once again confirms the validity of the MSKCC nomogram. The area under curve (AUC) was 0.919 (95 % CI: 0.869–0.969, P

Published
2016

2. Clinical implications of p57 KIP2 expression in breast cancer

Author

Yi-Ming Li, Miao Tang, Bo Chen, Liang Wei, Feng Jin, Nan Jiang, Shouliang Cai, Xiaoyin Xu, Lei Zhang, and Wenqian Wang

Subjects
Oncology, Adult, Cancer Research, medicine.medical_specialty, P57 kip2, Epidemiology, Receptor, ErbB-2, Subgroup analysis, Breast Neoplasms, Immunoenzyme Techniques, Breast cancer, Text mining, Internal medicine, Medicine, Humans, Breast, Cyclin-Dependent Kinase Inhibitor p57, Survival analysis, Aged, Neoplasm Staging, Aged, 80 and over, Proportional hazards model, business.industry, Carcinoma, Ductal, Breast, Public Health, Environmental and Occupational Health, Middle Aged, medicine.disease, Prognosis, Survival Rate, Case-Control Studies, Lymphatic Metastasis, Biomarker (medicine), Immunohistochemistry, Female, business, Follow-Up Studies
Abstract

Objective: To study the relationship between expression of p57 KIP2 and prognosis and other clinicopathological parameters in invasive breast cancers. Methods: We assessed the expression of p57 KIP2 in 89 cases of invasive breast cancer and 20 cases of normal breast tissue by immunohistochemical methods and analyzed the results with SPSS software (ver. 16.0). Result: The positive expression rates of p57 KIP2 protein in the invasive breast cancers and surrounding normal tissue were 30.3% (27/89) and 65% (13/20), respectively. Cases with no p57 KIP2 expression exhibited a significantly higher post-operative distant metastasis rate than those with p57 KIP2 expression (37.9% vs. 14.8%; P = 0.01). DFS analysis showed that p57 KIP2 -/C-erbB-2+ tumors also exhibited a significantly higher post-operative distant metastasis rate than the other groups (66.7% vs. 29.2%; P = 0.007), as did p57 KIP2 -/p53+ tumors (64.3% vs. 22.7%; P = 0.001). Survival analysis revealed that p57 KIP2 was associated with breast cancer-specific survival overall (P = 0.045, log-rank test). Subgroup analysis demonstrated that individuals with p57 KIP2 -/C-erbB-2+tumors experienced significantly worse post-operative survival than those with p57 KIP2 - /C-erbB-2- or other tumors (P = 0.006, log-rank test). p57 KIP2 -/p53+ tumors were associated with significantly worse post-operative survival than p57 KIP2 -/p53- or other tumors (P = 0.001, log-rank test). Cox regression analysis showed that p57 KIP2 was a non-independent prognostic factor for breast cancer (P = 0.303). Conclusions: p57 KIP2 is expressed at low levels in invasive breast cancer and is associated with better overall survival rate and disease-free survival in breast cancer patients, but it was a non-independent prognostic factor for breast cancer. Thus, the connection between p57 KIP2 /p53 and p57 KIP2 /C-erbB-2 may provide biomarkers for

Published
2012

3. POU5F1/Oct-4 expression in breast cancer tissue is significantly associated with non-sentinel lymph node metastasis.

Author

Shouliang Cai, Shugang Geng, Feng Jin, Jisheng Liu, Chang Qu, Bo Chen, Cai, Shouliang, Geng, Shugang, Jin, Feng, Liu, Jisheng, Qu, Chang, and Chen, Bo

Subjects
*BREAST cancer research, *SENTINEL lymph nodes, *LYMPHATIC metastasis, *TUMORS, *TISSUES, *PROTEIN metabolism, *BREAST tumors, *COMPARATIVE studies, *GENE expression, *IMMUNOHISTOCHEMISTRY, *RESEARCH methodology, *MEDICAL cooperation, *METASTASIS, *PROTEINS, *RESEARCH, *TUMOR classification, *EVALUATION research, *RETROSPECTIVE studies, *RECEIVER operating characteristic curves, *ODDS ratio, *TUMOR grading
Abstract

Background: At present, few studies have explored the significance of POU5F1 (also known as octamer-bingding factor, Oct-4 or Oct-3) expression in breast cancer tissues.Methods: A total of 121 patients were retrospectively selected between May 2010 and March 2013 to investigate the relationship between POU5F1/Oct-4 expression in breast cancer tissues and non-sentinel lymph node (non-SLN) metastases and to validate the Memorial Sloan-Kettering Cancer Center (MSKCC) nomogram. All patients had early-stage breast cancer, which was histologically confirmed by the Department of Surgical Oncology, The First Affiliated Hospital of China Medical University. Histological type and grade of tumors were determined from tissue samples by hematoxylin and eosin staining, while the presence of POU5F1/Oct-4 protein was determined by immunohistochemistry. POU5F1/Oct-4 expression levels in tissues obtained from patients with sentinel lymph node (SLN) and non-SLN metastasis and in tissues obtained from patients without lymph node metastases were compared.Results: POU5F1/Oct-4 expression levels in breast cancer tissues were significantly higher in both the SLN metastasis and non-SLN metastasis groups (P = 0.003 and P = 0.030, respectively). Furthermore, POU5F1/Oct-4 expression was found to be associated to both histological (P = 0.01) and molecular type (P = 0.03). Thus, our data once again confirms the validity of the MSKCC nomogram. The area under curve (AUC) was 0.919 (95 % CI: 0.869-0.969, P < 0.001). The probability of non-SLN metastasis generated from the MSKCC nomgram was significantly higher in the POU5F1/Oct-4 positive group than in the POU5F1/Oct-4 negative group. Both univariate and multivariate analysis revealed that Oct-4 expression levels were significantly associated with non-SLN metastases (P = 0.030 and P = 0.034, respectively).Conclusions: POU5F1/Oct-4 expression levels are significantly associated with non-SLN metastases. Patients with higher probabilities of metastasis generated from the MSKCC nomogram may also have higher POU5F1/Oct-4 expression levels. [ABSTRACT FROM AUTHOR]

Published
2016
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