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Your search keyword '"Zheng-Gen Wang"' showing total 4 results
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4 results on '"Zheng-Gen Wang"'

1. Retraction Note to: High expression level and nuclear localization of Sam68 are associated with progression and poor prognosis in colorectal cancer

Author

Yan Mei Cui, Ling Shi, Li Bing Song, Zheng Gen Wang, Yan Qing Ding, Xiaohui Zhao, Tingting Li, Wen Ting Liao, Xiu Ting Chen, and Jun Ling Liu

Subjects
medicine.medical_specialty, business.industry, Colorectal cancer, Gastroenterology, Cancer, General Medicine, RC799-869, Hepatology, Diseases of the digestive system. Gastroenterology, medicine.disease_cause, medicine.disease, Blot, Internal medicine, medicine, Cancer research, T-stage, Immunohistochemistry, Carcinogenesis, business, Nuclear localization sequence
Abstract

Src-associated in mitosis (Sam68; 68 kDa) has been implicated in the oncogenesis and progression of several human cancers. The aim of this study was to investigate the clinicopathologic significance of Sam68 expression and its subcellular localization in colorectal cancer (CRC). Sam68 expression was examined in CRC cell lines, nine matched CRC tissues and adjacent noncancerous tissues using reverse transcription (RT)-PCR, quantitative RT-PCR and Western blotting. Sam68 protein expression and localization were determined in 224 paraffin-embedded archived CRC samples using immunohistochemistry. Statistical analyses were applied to evaluate the clinicopathologic significance. Sam68 was upregulated in CRC cell lines and CRC, as compared with normal tissues; high Sam68 expression was detected in 120/224 (53.6%) of the CRC tissues. High Sam68 expression correlated significantly with poor differentiation (P = 0.033), advanced T stage (P

Published
2021

2. RETRACTED ARTICLE: High expression level and nuclear localization of Sam68 are associated with progression and poor prognosis in colorectal cancer

Author

Wen Ting Liao, Xiu Ting Chen, Xiaohui Zhao, Yan Qing Ding, Tingting Li, Ling Shi, Zheng Gen Wang, Li Bing Song, Yan Mei Cui, and Jun Ling Liu

Subjects
medicine.medical_specialty, Pathology, business.industry, Colorectal cancer, Gastroenterology, General Medicine, Hepatology, medicine.disease_cause, Subcellular localization, medicine.disease, Biomarker (cell), Internal medicine, medicine, Cancer research, Immunohistochemistry, Carcinogenesis, business, Mitosis, Survival analysis
Abstract

Background Src-associated in mitosis (Sam68; 68 kDa) has been implicated in the oncogenesis and progression of several human cancers. The aim of this study was to investigate the clinicopathologic significance of Sam68 expression and its subcellular localization in colorectal cancer (CRC). Methods Sam68 expression was examined in CRC cell lines, nine matched CRC tissues and adjacent noncancerous tissues using reverse transcription (RT)-PCR, quantitative RT-PCR and Western blotting. Sam68 protein expression and localization were determined in 224 paraffin-embedded archived CRC samples using immunohistochemistry. Statistical analyses were applied to evaluate the clinicopathologic significance. Results Sam68 was upregulated in CRC cell lines and CRC, as compared with normal tissues; high Sam68 expression was detected in 120/224 (53.6%) of the CRC tissues. High Sam68 expression correlated significantly with poor differentiation (P = 0.033), advanced T stage (P P = 0.023) and distant metastasis (P = 0.033). Sam68 nuclear localization correlated significantly with poor differentiation (P = 0.002) and T stage (P =0.021). Patients with high Sam68 expression or Sam68 nuclear localization had poorer overall survival than patients with low Sam68 expression or Sam68 cytoplasmic localization. Patients with high Sam68 expression had a higher risk of recurrence than those with low Sam68 expression. Conclusions Overexpression of Sam68 correlated highly with cancer progression and poor differentiation in CRC. High Sam68 expression and Sam68 nuclear localization were associated with poorer overall survival.

Published
2013
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3. High expression level and nuclear localization of Sam68 are associated with progression and poor prognosis in colorectal cancer.

Author

Wen-Ting Liao, Jun-Ling Liu, Zheng-Gen Wang, Yan-Mei Cui, Ling Shi, Ting-Ting Li, Xiao-Hui Zhao, Xiu-Ting Chen, Yan-Qing Ding, Li-Bing Song, Liao, Wen-Ting, Liu, Jun-Ling, Wang, Zheng-Gen, Cui, Yan-Mei, Shi, Ling, Li, Ting-Ting, Zhao, Xiao-Hui, Chen, Xiu-Ting, Ding, Yan-Qing, and Song, Li-Bing

Subjects
MITOSIS, CARCINOGENESIS, NEOPLASTIC cell transformation, COLON cancer, CELL lines, IMMUNOHISTOCHEMISTRY, CANCER invasiveness, CELL culture
Abstract

Background: Src-associated in mitosis (Sam68; 68 kDa) has been implicated in the oncogenesis and progression of several human cancers. The aim of this study was to investigate the clinicopathologic significance of Sam68 expression and its subcellular localization in colorectal cancer (CRC).Methods: Sam68 expression was examined in CRC cell lines, nine matched CRC tissues and adjacent noncancerous tissues using reverse transcription (RT)-PCR, quantitative RT-PCR and Western blotting. Sam68 protein expression and localization were determined in 224 paraffin-embedded archived CRC samples using immunohistochemistry. Statistical analyses were applied to evaluate the clinicopathologic significance.Results: Sam68 was upregulated in CRC cell lines and CRC, as compared with normal tissues; high Sam68 expression was detected in 120/224 (53.6%) of the CRC tissues. High Sam68 expression correlated significantly with poor differentiation (P = 0.033), advanced T stage (P < 0.001), N stage (P = 0.023) and distant metastasis (P = 0.033). Sam68 nuclear localization correlated significantly with poor differentiation (P = 0.002) and T stage (P =0.021). Patients with high Sam68 expression or Sam68 nuclear localization had poorer overall survival than patients with low Sam68 expression or Sam68 cytoplasmic localization. Patients with high Sam68 expression had a higher risk of recurrence than those with low Sam68 expression.Conclusions: Overexpression of Sam68 correlated highly with cancer progression and poor differentiation in CRC. High Sam68 expression and Sam68 nuclear localization were associated with poorer overall survival. [ABSTRACT FROM AUTHOR]

Published
2013
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4. High expression level and nuclear localization of Sam68 are associated with progression and poor prognosis in colorectal cancer

Author

Wen-Ting, Liao, Jun-Ling, Liu, Zheng-Gen, Wang, Yan-Mei, Cui, Ling, Shi, Ting-Ting, Li, Xiao-Hui, Zhao, Xiu-Ting, Chen, Yan-Qing, Ding, and Li-Bing, Song

Subjects
Adult, Male, Young Adult, Cell Line, Tumor, Biomarkers, Tumor, Humans, RNA, Messenger, Adaptor Proteins, Signal Transducing, Aged, Aged, 80 and over, Gastroenterology, RNA-Binding Proteins, Biomarker, Middle Aged, Prognosis, Immunohistochemistry, Survival Analysis, Colorectal cancer, Up-Regulation, DNA-Binding Proteins, Retraction Note, Lymphatic Metastasis, Sam68, Disease Progression, Female, Colorectal Neoplasms, Research Article
Abstract

Background Src-associated in mitosis (Sam68; 68 kDa) has been implicated in the oncogenesis and progression of several human cancers. The aim of this study was to investigate the clinicopathologic significance of Sam68 expression and its subcellular localization in colorectal cancer (CRC). Methods Sam68 expression was examined in CRC cell lines, nine matched CRC tissues and adjacent noncancerous tissues using reverse transcription (RT)-PCR, quantitative RT-PCR and Western blotting. Sam68 protein expression and localization were determined in 224 paraffin-embedded archived CRC samples using immunohistochemistry. Statistical analyses were applied to evaluate the clinicopathologic significance. Results Sam68 was upregulated in CRC cell lines and CRC, as compared with normal tissues; high Sam68 expression was detected in 120/224 (53.6%) of the CRC tissues. High Sam68 expression correlated significantly with poor differentiation (P = 0.033), advanced T stage (P

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