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Start Over Author "Read, Tony" Topic immunological tolerance
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1. Treatment Outcomes Stratified by Baseline Immunological Status among Young Children Receiving Nonnucleoside Reverse-Transcriptase Inhibitor--Based Antiretroviral Therapy in Resource-Limited Settings.

Author

O'Brien, Daniel P., Sauvageot, Delphine, Olson, David, Schaeffer, Myrto, Humblet, Pierre, Pudjades, Mar, Ellman, Tom, Zachariah, Rony, Szumilin, Elisabeth, Arnould, Line, and Read, Tony

Subjects
CHILDREN, ANTIRETROVIRAL agents, REVERSE transcriptase, NUCLEOSIDES, IMMUNOLOGICAL tolerance, THERAPEUTICS
Abstract

A study of 568 children aged <5 years who commenced nonnucleoside reverse-transcriptase inhibitor-based antiretroviral therapy in resource-limited settings revealed good early outcomes. After 12 months of antiretroviral therapy, survival probability was 0.89 (95% confidence interval, 0.86-0.92), with no significant difference among children stratified on the basis of baseline immunological levels; 62% attained a CD4 cell percentage >25%, and 7% continued to have a CD4 cell percentage <15%. [ABSTRACT FROM AUTHOR]

Published
2007
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