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Your search keyword '"Yered H. Pita-Juarez"' showing total 1 results
Start Over Author "Yered H. Pita-Juarez" Topic immunology
1 results on '"Yered H. Pita-Juarez"'

1. Serine and arginine rich splicing factor 1 deficiency alters pathways involved in IL-17A expression and is implicated in human psoriasis

Author

Shi Su, Xanthi-Lida Katopodi, Yered H. Pita-Juarez, Emanual Maverakis, Ioannis S. Vlachos, and Iannis E. Adamopoulos

Subjects
Alternative Splicing, Mice, Serine-Arginine Splicing Factors, Immunology, Interleukin-17, Serine, Immunology and Allergy, Animals, Humans, Psoriasis, RNA Splicing Factors, Arginine
Abstract

Serine and Arginine Rich Splicing Factor 1 (SRSF1) is a splicing factor that binds to exonic enhancers and stimulates splicing and is previously implicated with autoimmunity. Herein, we investigate the role of SRSF1 in regulating innate immune functions that are pertinent in the pathogenesis of auto-inflammatory diseases. Specifically, we show that conditional deletion of SRSF1 in mature lymphocytes resulted in higher expression of il-17a and il-17 f and an expansion of IL17A

Published
2022

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