1. Current and future immunotherapeutic approaches in Hodgkin lymphoma.
- Author
-
Bröckelmann PJ, Borchmann P, and Engert A
- Subjects
- Antigens, Neoplasm, Antineoplastic Agents, Immunological pharmacology, Antineoplastic Agents, Immunological therapeutic use, Biomarkers, Tumor, Cell- and Tissue-Based Therapy, Combined Modality Therapy, Hodgkin Disease genetics, Hodgkin Disease metabolism, Hodgkin Disease pathology, Humans, Immunoconjugates pharmacology, Immunoconjugates therapeutic use, Immunotoxins pharmacology, Immunotoxins therapeutic use, Molecular Targeted Therapy, Treatment Outcome, Hodgkin Disease therapy, Immunotherapy adverse effects, Immunotherapy methods
- Abstract
Hodgkin lymphoma (HL) has become a highly curable malignancy even in advanced stages when treated adequately. However, relapsed or refractory disease and treatment-related toxicity constitute a significant clinical challenge. Innovative approaches are thus needed to improve treatment of these mainly young patients. In HL lesions, very few malignant Hodgkin and Reed-Sternberg (HRS) cells are embedded in an immunosuppressive microenvironment of reactive cells. Novel approaches such as bispecific antibodies, antibody-drug conjugates, immune-checkpoint inhibitors or adoptive cellular therapies are currently being investigated with promising results in relapsed or refractory patients. Encouraging response rates and a favorable toxicity profile have recently been reported in early phase clinical trials with antibodies blocking the programed-death receptor 1 (PD1). This review will summarize the current clinical knowledge on mechanism, safety and efficacy of the different agents and discuss potential future strategies, which are partly already investigated within clinical trials.
- Published
- 2016
- Full Text
- View/download PDF