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Your search keyword '"Xinru Li"' showing total 5 results
Start Over Author "Xinru Li" Topic in vitro release
5 results on '"Xinru Li"'

1. Preparation and Evaluation of Poly(Ethylene Glycol)–Poly(Lactide) Micelles as Nanocarriers for Oral Delivery of Cyclosporine A

Author

Yanqing Huang, Xinru Li, Yan Liu, Xiaoning Wang, Yanxia Zhou, Yating Fan, and Yanhui Zhang

Subjects
Drug, Materials science, media_common.quotation_subject, Nanotechnology, Micelle, Intestinal absorption, chemistry.chemical_compound, Cyclosporine A, Materials Science(all), Copolymer, General Materials Science, Chemistry/Food Science, general, media_common, Lactide, Nano Express, Material Science, Engineering, General, technology, industry, and agriculture, Materials Science, general, Monomethoxy poly(ethylene glycol)–poly(lactide), In vitro release, Solubility parameter, Condensed Matter Physics, Hildebrand solubility parameter, Physics, General, chemistry, Molecular Medicine, Polymeric micelles, Nanocarriers, Ethylene glycol, Nuclear chemistry
Abstract

A series of monomethoxy poly(ethylene glycol)–poly(lactide) (mPEG–PLA) diblock copolymers were designed according to polymer–drug compatibility and synthesized, and mPEG–PLA micelle was fabricated and used as a nanocarrier for solubilization and oral delivery of Cyclosporine A (CyA). CyA was efficiently encapsulated into the micelles with nanoscaled diameter ranged from 60 to 96 nm with a narrow size distribution. The favorable stabilities of CyA-loaded polymeric micelles were observed in simulated gastric and intestinal fluids. The in vitro drug release investigation demonstrated that drug release was retarded by polymeric micelles. The enhanced intestinal absorption of CyA-loaded polymeric micelles, which was comparable to the commercial formulation of CyA (Sandimmun Neoral®), was found. These suggested that polymeric micelles might be an effective nanocarrier for solubilization of poorly soluble CyA and further improving oral absorption of the drug.

Published
2010

2. Preparation and characterization of dual pH-sensitive polymer-doxorubicin conjugate micelles.

Author

Yang Zou, Yao Jin, Yuanhang Zhou, Chuyu He, Yunqiang Deng, Shidi Han, Chuhang Zhou, Xinru Li, Yanxia Zhou, and Yan Liu

Subjects
MICELLES, DOXORUBICIN, TUMOR growth, CONJUGATED polymers, NUCLEAR magnetic resonance
Abstract

Copyright of Journal of Chinese Pharmaceutical Sciences is the property of Journal of Chinese Pharmaceutical Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2018
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3. Preparation and characterization of intestinal transporter -targeted polymeric micelles.

Author

Chuyu He, Yao Jin, Yunqiang Deng, Yang Zou, Shidi Han, Chuhang Zhou, Yuanhang Zhou, Xinru Li, Yanxia Zhou, and Yan Liu

Subjects
MICELLES synthesis, CARRIER proteins, ORGANIC cation transporters, CARNITINE, INTESTINAL absorption
Abstract

Copyright of Journal of Chinese Pharmaceutical Sciences is the property of Journal of Chinese Pharmaceutical Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2018
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4. Preparation and characterization of intestine PepT1-targeted calcium carbonate nanoparticles.

Author

Yunqiang Deng, Yao Jin, Chuyu He, Yang Zou, Yuanhang Zhou, Shidi Han, Chuhang Zhou, Qi Liu, Xinru Li, Yanxia Zhou, and Yan Liu

Subjects
CALCIUM carbonate, NANOPARTICLE synthesis, TRANSCYTOSIS, INTESTINAL absorption, SCANNING electron microscopy
Abstract

Copyright of Journal of Chinese Pharmaceutical Sciences is the property of Journal of Chinese Pharmaceutical Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2018
Full Text
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5. Preparation and Evaluation of Poly(Ethylene Glycol)–Poly(Lactide) Micelles as Nanocarriers for Oral Delivery of Cyclosporine A.

Author

Yanhui Zhang, Xinru Li, Yanxia Zhou, Xiaoning Wang, Yating Fan, Yanqing Huang, and Yan Liu

Subjects
POLYMERS, IMMUNOSUPPRESSIVE agents, CYCLOSPORINE, POLYETHYLENE, THERMOPLASTICS
Abstract

A series of monomethoxy poly(ethylene glycol)–poly(lactide) (mPEG–PLA) diblock copolymers were designed according to polymer–drug compatibility and synthesized, and mPEG–PLA micelle was fabricated and used as a nanocarrier for solubilization and oral delivery of Cyclosporine A (CyA). CyA was efficiently encapsulated into the micelles with nanoscaled diameter ranged from 60 to 96 nm with a narrow size distribution. The favorable stabilities of CyA-loaded polymeric micelles were observed in simulated gastric and intestinal fluids. The in vitro drug release investigation demonstrated that drug release was retarded by polymeric micelles. The enhanced intestinal absorption of CyA-loaded polymeric micelles, which was comparable to the commercial formulation of CyA (Sandimmun Neoral®), was found. These suggested that polymeric micelles might be an effective nanocarrier for solubilization of poorly soluble CyA and further improving oral absorption of the drug. [ABSTRACT FROM AUTHOR]

Published
2010
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