Search

Background Circulatory and vascular changes across consecutive pregnancies may increase the risk of later-life cerebrovascular health outcomes. Methods The association between parity and incident stroke was assessed among 7674 white and 6280 black women, aged 45 years and older, and enrolled in the REasons for Geographic and Racial Differences in Stroke Study from 2003 to 2007. Parity was assessed at baseline, and incident stroke was ascertained from physician-adjudicated medical records through September 2014. Cox proportional hazards models were used to estimate hazard ratios (HR) for the association between parity and stroke, adjusting for baseline measures. Results At baseline, 12.7% of white women and 16.2% of black women reported 1 live birth, while 8.2% and 19.0%, respectively, reported 5 or more live births. Mean follow-up time was 7.5 years (standard deviation = 2.8); there were 447 incident strokes. A significant interaction between race and parity was detected ( P = .05). Among white women, those with 5 or more live births had a higher stroke risk than those with 1 live birth (HR = 1.57; 95% confidence interval [CI] .93-2.65). However, the association was eliminated after adjustment for baseline characteristics (HR = 1.00, 95% CI .59-1.71). For black women, those with 5 or more live births had the highest stroke risk compared with those with 1 live birth (HR = 1.91, 95% CI 1.25-2.93), but the association was attenuated and no longer statistically significant after adjustment for confounders (HR = 1.40, 95% CI .89-2.18). Conclusions In adjusted models, no statistically significantassociations were observed between parity and stroke risk in a diverse cohort of U.S. women. Further studies are needed to elucidate the role of lifestyle and psychosocial factors in the race-specific associations that were observed.

Objectives This study examines the relationship between alcohol consumption and incident stroke among older adults and tests whether alcohol consumption contributes to observed race and sex differences in stroke. Method Data are from a U.S. national cohort of black and white adults aged 45 and older, the REasons for Geographic And Racial Differences in Stroke (REGARDS) study. Current and past drinking levels were reported at baseline (2003-2007). Participants who had never had a stroke were followed for adjudicated stroke events through September 2015 (n = 27,265). We calculated Cox proportional hazard models for stroke, adjusting for demographic, socioeconomic, behavioral, and health characteristics. Results Participants, mean age 64.7 years, consumed on average 2.2 drinks/week and experienced 1,140 first-time stroke events over median 9.1 years follow-up. Nondrinkers had a 12% higher risk of stroke than current drinkers; the risk of stroke among nondrinkers largely reflected high risks among past drinkers; these differences were explained by socioeconomic characteristics. Among current drinkers, light drinkers had significantly lower stroke risks than moderate drinkers after accounting for demographic, socioeconomic, behavioral, and health characteristics. Implications of alcohol did not differ between blacks and whites but did differ by sex: Especially among women, nondrinkers, and specifically past drinkers, had higher risks; these differences were largely explained by health characteristics and behaviors. Alcohol did not explain race and sex differences in stroke incidence. Discussion Among older adults, those who used to, but no longer, drink had higher risks of stroke, especially among women; current light drinkers had the lowest risk of stroke.

Current definitions of hypertension are primarily based on systolic blood pressure (SBP) and diastolic blood pressure (DBP) but not on pulse pressure (PP). More recently, increased attention has been given to PP as a predictor of stroke risk, with PP hypothesized to be an indicator of the stiffness of large arteries, especially the aorta.1–4 SBP and DBP increase with age in a parallel manner until about age 60, after which SBP continues to rise and DBP begins to decrease. This age-related phenomenon results in the large increase in PP after age 60 and an increase in the prevalence of isolated systolic hypertension.5 As a result, PP may be a key blood pressure (BP) measure in older individuals and may be important as a risk factor for cardiovascular disease, including stroke, myocardial infarction (MI), and death.3 Some evidence suggests PP may be an independent predictor of stroke, even independent of SBP.6Although studies have explored a possible relationship between PP and occurrence of stroke events, most of these studies have included predominantly white populations.2,5 Few data on this subject are available in African-Americans (AA), and it is unclear if there is a correlation between PP and the incidence of stroke in this population. Differences in the association of PP and stroke between women and men have also been reported, but not extensively.1 The primary purpose of this study was to further investigate if PP is a useful predictor for stroke risk. We postulated that differences in PP, independent of SBP may represent one possible contributor to the racial differences in stroke risk. As such, The REasons for Geographic And Racial Differences in Stroke (REGARDS) could provide valuable information as to whether racial differences exist relative to PP, and its effect on incident stroke. We also explored whether AAs have a greater stroke risk at same PP compared with whites (that is a differential susceptibility compared with whites), and if regional differences in that association exist.

The association between lipid levels and stroke rates is less than lipid levels and coronary heart disease (CHD).To assess if there are geographic, racial, and ethnic differences in total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and triglyceride levels with incident stroke.From the REasons for Geographic And Racial Differences in Stroke (REGARDS) study we evaluated baseline levels of LDL-C, HCL-C, TC, Non-HDL-C (Total-HDL-C) and triglycerides in participants free of prevalent stroke at baseline. Cox Proportional-Hazard models were the main analytical tool used to examine the association between incident stroke and lipids. For each adjusted lipid measure (LDL-C, HDL-C, triglycerides, TC, and non-HDL-C) we calculated a series of incremental models.The analysis cohort was 23,867 participants with a mean follow-up time of 7.5±2.9years, and 1031 centrally adjudicated strokes (874 ischemic and 77 hemorrhagic strokes). HDL-C baseline level was associated with an overall unadjusted 13% risk reduction (HR 0.87, 95% confidence interval [CI]: 0.81-0.93; p0.05; 14% for ischemic and 16% for hemorrhagic strokes), and TC with an 8% (HR 0.92, 95%CI: 0.87-0.99; p0.05) risk reduction of all strokes. When the results were fully adjusted a significant association was observed only for LDL-C and non-HDL-C and ischemic stroke. There were no significant differences in these associations when adjusted for age, race, age∗race, gender, education, region, or income.In a disease free population, LDL-C and non-HDL-C baseline levels are significantly associated with the risk of ischemic stroke.