13 results on '"Mahanta, J."'
Search Results
2. Prevalence of β-thalassemia and other haemoglobinopathies in six cities in India: a multicentre study
- Author
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Mohanty, D., Colah, R. B., Gorakshakar, A. C., Patel, R. Z., Master, D. C., Mahanta, J., Sharma, S. K., Chaudhari, U., Ghosh, M., Das, S., Britt, R. P., Singh, S., Ross, C., Jagannathan, L., Kaul, R., Shukla, D. K., and Muthuswamy, V.
- Published
- 2013
- Full Text
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3. Anaemia & expression levels of CD35, CD55 & CD59 on red blood cells in Plasmodium falciparum malaria patients from India
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Mahajan, R.C., Narain, K., and Mahanta, J.
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Adult ,Male ,Erythrocytes ,Adolescent ,Plasmodium falciparum ,India ,Anaemia ,CD59 Antigens ,Young Adult ,Goa ,parasitic diseases ,Humans ,Malaria, Falciparum ,Assam ,Child ,CR1 ,Aged ,CD55 Antigens ,Infant ,Anemia ,Middle Aged ,Chennai ,Child, Preschool ,Receptors, Complement 3b ,flowcytometry ,Original Article ,Female ,CD55 ,CD59 - Abstract
Background & objectives: Severe anaemia in Plasmodium falciparum (Pf) associated malaria is a leading cause of death despite low levels of parasitaemia. In an effort to understand the pathogenesis of anaemia we studied expression level of RBC complement regulatory proteins, CR1 (CD35), CD55 and CD59 with haemoglobin status in a group of malaria cases from Assam, Goa and Chennai, and in healthy controls. Methods: Flowcytometry was used to study expression of CR1, CD55 and CD59 in 50 Pf cases and 30 normal healthy volunteers. Giemsa stained thick and thin blood films were used for microscopic detection and identification of malarial parasites and parasite count. Results: No correlation was found between degree of expression of RBC surface receptors CR1, CD55 and CD59 with haemoglobin level. However, expression of CD55 was less in malaria cases than in healthy controls. Interpretation & conclusions: The present findings indicate that malaria infection changes the expression profile of complement regulatory protein CD55 irrespective of severity status of anaemia. Further studies are needed to explore the pathophysiology of anaemia in malaria cases in Assam where expression of RBC complement receptors appears to be low even in normal healthy population.
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- 2011
4. Interaction of Iron Deficiency Anemia and Hemoglobinopathies Among College Students and Pregnant Women: A Multi Center Evaluation in India.
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Mohanty, Dipika, Gorakshakar, Ajit C., Colah, Roshan B., Patel, Ramesh Z., Master, Dilip C., Mahanta, J., Sharma, Santanu K., Chaudhari, Utpal, Ghosh, Malay, Das, Sheila, Britt, Reitt P., Singh, Shawinder, Ross, Cecil, Jagannathan, Lata, Kaul, Rajni, Shukla, Deepak K., and Muthuswamy, Vasantha
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COLLEGE students ,THALASSEMIA ,IRON deficiency anemia ,PREGNANT women - Abstract
Although iron deficiency anemia is very common in India, systematic large studies on the prevalence and hematological consequences of iron deficiency among carriers of β-thalassemia (β-thal) and other hemoglobinopathies are lacking. A multi center project was undertaken to screen college/university students and pregnant women for iron deficiency anemia and various hemoglobinopathies. Fifty-six thousand, seven hundred and seventy-two subjects from six states, Maharashtra, Gujarat, Karnataka, West Bengal, Assam and Punjab, were studied. Iron deficiency anemia was evaluated by measuring zinc protoporphyrin (ZPP) and hemoglobin (Hb) levels, while β-thal and other hemoglobinopathies were detected by measuring the red cell indices and by Hb analysis using high performance liquid chromatography (HPLC). College boys (2.2%), college girls (14.3%) and antenatal women (27.0%) without any hemoglobinopathies had iron deficiency anemia. Among the β-thal carriers, the prevalence of iron deficiency anemia was 17.3% in college boys, 38.1% in college girls and 55.9% in pregnant women, while in the Hb E [β26(B8)Glu→Lys; HBB: c.79G>A] carriers, it was 7.3% in college boys, 25.4% in college girls and 78.0% in antenatal women. In individuals with Hb E disease, the prevalence of iron deficiency anemia varied from 31.2-77.3% in the three groups. A significant reduction in Hb levels was seen when iron deficiency anemia was associated with hemoglobinopathies. However, the Hb A
2 levels in β-thal carriers were not greatly reduced in the presence of iron deficiency anemia. [ABSTRACT FROM AUTHOR]- Published
- 2014
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5. Syphilis infection among female sex workers in Nagaland, Northeast India: analysing their vulnerability to the infection.
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Medhi, G. K., Mahanta, J., Hazarika, I., Armstrong, G., Adhikary, R., Mainkar, M., and Paranjape, R. S.
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SYPHILIS ,HIV infections ,CONDOM use ,SEX workers - Abstract
This paper describes the sex work characteristics and factors associated with syphilis among female sex workers (FSWs) in Dimapur district of high HIV prevalence Indian state, Nagaland. The study recruited 426 FSWs in 2006 using respondentdriven sampling. The prevalence of syphilis was 21.1% and HIV prevalence was 11.7%. Approximately half were under 25 years of age. Clients were solicited mainly in public places (32.7%), while hotels/lodges/rented rooms were the most common places of entertainment (57.2%). Condom use during the last sex was 36.5% with occasional and 27% with regular clients. Being married, being widowed/divorced/separated, being illiterate or having a history of drug use increased the likelihood of syphilis infection. Entertaining clients in bars/booze joints decreased the probability of syphilis. FSWs who moved between soliciting in public places or bars/booze joints and then entertaining in hotels/lodges/rented rooms had a higher vulnerability to syphilis. In summary, we found that the vulnerability to syphilis among mostly young FSWs in Dimapur varied according to their sex work characteristics, marital and educational status and drug use habits. They may be more vulnerable to HIV and sexually transmitted infections (HIV/STIs) due to the low rate of condom use. The findings have direct implications for HIV/STI prevention programmes in Northeast India. [ABSTRACT FROM AUTHOR]
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- 2013
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6. Malaria control in a forest fringe area of Assam, India: a pilot study
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Dutta, P., Khan, A.M., Khan, S.A., Borah, J., Sharma, C.K., and Mahanta, J.
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MALARIA prevention ,INSECTICIDE-treated mosquito nets ,INSECT baits & repellents ,ANOPHELES ,FOREST ecology ,MOSQUITO vectors - Abstract
Summary: A study was conducted to evaluate the preventive efficacy of insecticide-treated mosquito nets (ITMNs) and mosquito repellent (MR) in a malaria-endemic foothill area of Assam, India, with forest ecosystem. During the first year, a survey was conducted in four demarcated sectors (A–D) to observe the malaria endemicity and vector prevalence patterns before implementing intervention measures. All four sectors were endemic for malaria. The prevalence of established malaria vectors such as Anopheles dirus, A. minimus and A. philippinensis was observed. During the second year, intervention measures were implemented in the four sectors as follows: A, ITMN + MR; B, ITMN; C, MR; D, no intervention. The most effective intervention was in sector A, followed by sectors B and C. Sectors A and B exhibited significantly higher (P < 0.001) malaria protective efficacy during both the first and second years of intervention compared with sector D. The total vector population in the three intervention sectors decreased significantly compared with that of the non-intervention one. Information–education–communication activities motivated the residents to participate actively in the intervention programme. The finding could be an effective model for containment of high malaria morbidity in inaccessible forest fringe areas of the northeastern region of India. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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7. A novel HBV recombinant (genotype I) similar to Vietnam/Laos in a primitive tribe in eastern India.
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Arankalle, V. A., Gandhe, S. S., Borkakoty, B. J., Walimbe, A. M., Biswas, D, and Mahanta, J
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HEPATITIS B virus ,RECOMBINANT viruses ,GENETIC polymorphisms ,GENOMES ,LIVER diseases - Abstract
Genotyping of 20 strains of Hepatitis B virus (HBV) from the Idu Mishmi primitive tribe of northeast India identified multiple genotypes and the presence of a unique cluster grouping with strains from Vietnam and Laos identified as novel recombinants/genotype I. Sequence analysis (similarity and bootscan plots) of three complete HBV genomes from the tribe provided evidence of recombination. Phylogenetic analyses supported recombination between genotypes A, G and C. The Pre-S gene between nt 2943 and 397 was clearly of genotype A origin, whereas nt 397–1397 represented genotype G and nt 1397–2943 represented genotype C. Percentage divergence from genotypes B, D, E, F, G and H varied from 9.2 ± 0.45% to 13.8 ± 0.53%, whereas genotype A and C differed by 7.9 ± 0.42% and 7.4 ± 0.39% respectively. The identification of similar recombinant viruses in three countries, especially in a primitive tribe with no contact with the outside world suggests that these viruses do not represent recent recombination events, but circulation of closely related viruses highly divergent from known HBV genotypes and should be classified as members of genotype ‘I’. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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8. Pleuropulmonary paragonimiasis due to Paragonimus heterotremus: molecular diagnosis, prevalence of infection and clinicoradiological features in an endemic area of northeastern India
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Devi, K. Rekha, Narain, Kanwar, Bhattacharya, S., Negmu, K., Agatsuma, Takeshi, Blair, David, Wickramashinghe, S., and Mahanta, J.
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PUBLIC health ,HEALTH ,HUMAN services ,COMMUNICABLE diseases ,HEALTH education - Abstract
Summary: In the northeastern region of India, paragonimiasis is emerging as an important public health problem. However, until now the identity of the species causing human infection has been uncertain and there has been little information on the prevalence and clinicoradiological features of infection in the community. Parasitological and immunological surveys revealed that paragonimiasis was hyperendemic in parts of Arunachal Pradesh. Egg positivity in the sputum was 20.9% and 4.1% in children (age ≤15 years) and adults (age >15 years), respectively. Antibody positivity against excretory–secretory antigen of the adult worm in children and adults was 51.7% and 18.7%, respectively. Chronic cough (97.2%) and haemoptysis (83.3%) were common respiratory symptoms among egg-positive cases. Chest radiography (n =68) images from egg-positive cases showed that air space consolidation (75%), cavitary lesions (14.7%) and mediastinal adenopathy (11.8%) were very frequent. Less frequent findings were nodular lesions, bronchiectasis, mediastinal adenopathy, pleural thickening and pleural effusion. DNA extracted from eggs from the sputum of patients from Arunachal Pradesh was sequenced. Analyses of the second internal transcribed spacer (ITS2) of nuclear rDNA revealed that the species responsible is Paragonimus heterotremus. [Copyright &y& Elsevier]
- Published
- 2007
- Full Text
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9. A cholera epidemic in a rural area of northeast India
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Phukan, A.C., Borah, P.K., Biswas, D., and Mahanta, J.
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DIARRHEA ,VIBRIO infections ,ANTI-infective agents ,SANITATION - Abstract
Sporadic cases of acute diarrhoea with high morbidity occur commonly in rural areas of northeast India, throughout the year. At times they take epidemic form and one such outbreak occurred with attack and case fatality rates of 11.6% and 0.8%, respectively, in October 2002, in a remote locality of Assam. Vibrio cholerae O1 El Tor Ogawa was isolated in 63% of hospitalized acute diarrhoea patients. Ineffective antibacterial treatment, poor hygiene practices and bad peridomestic sanitation were the factors associated with the persistence and spread of the pathogen, leading to the outbreak of cholera, resistant to commonly-used antimicrobials. [Copyright &y& Elsevier]
- Published
- 2004
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10. Declining prevalence of pulmonary paragonimiasis following treatment & community education in a remote tribal population of Arunachal Pradesh, India
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Kanwar Narain, Rekha Devi, K., Bhattacharya, S., Negmu, K., Rajguru, S. K., and Mahanta, J.
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Male ,Communicable Diseases - Original Articles ,Community education ,treatment ,Adolescent ,Paragonimiasis ,prevalence ,Sputum ,India ,tribal ,Feces ,Population Groups ,Humans ,Female ,Public Health ,Health Education - Abstract
Background & objectives: In India, human pulmonary paragonimiasis is an important public health problem in the northeastern (NE) region. In 2005 we reported a hyperendemic focus of paragonimiasis in a remote tribal village in the hills of Changlang district in Arunachal Pradesh. The community was made aware of the disease and all active cases were treated. This study was aimed to assess the decline in the prevelance of paragonimiasis in the same area after a re-survey done in 2011 after a gap of six years. Methods: Re-surveys were carried to determine the reduction in the prevalence of paragonimiasis. Community education was given to the villagers to raise their awareness about paragonimiasis. A total of 624 individuals including 301 children (age < 15 yr) were included in the study. Sputum and stool samples were examined for eggs of lung flukes. Serum samples were screened for IgG antibodies against lung fluke antigen by ELISA. Results: A significant (P
11. Larvicidal activity of few select indigenous plants of North East India against disease vector mosquitoes (Diptera: Culicidae)
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Chandrajit Dohutia, Dr, Bhattacharyya, Sk, Sharma, Pk, Mohapatra, Bhattacharjee K, Gogoi K, Gogoi P, Mahanta J, and Prakash A
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Insecticides ,Plant Extracts ,India ,Plant Roots ,Survival Analysis ,Culex ,Derris ,Aedes ,Thymelaeaceae ,Larva ,Anopheles ,Animals ,Biological Assay ,Croton - Abstract
Mosquitoes are the vectors of several life threatening diseases like dengue, malaria, Japanese encephalitis and lymphatic filariasis, which are widely present in the north-eastern states of India. Investigations on five local plants of north-east India, selected on the basis of their use by indigenous communities as fish poison, were carried out to study their mosquito larvicidal potential against Anopheles stephensi (malaria vector), Stegomyia aegypti (dengue vector) and Culex quinquefasciatus (lymphatic filariasis vector) mosquitoes. Crude Petroleum ether extracts of the roots of three plants viz. Derris elliptica, Linostoma decandrum and Croton tiglium were found to have remarkable larvicidal activity; D. elliptica extract was the most effective and with LC50 value of 0.307 μg/ml its activity was superior to propoxur, the standard synthetic larvicide. Half-life of larvicidal activity of D. elliptica and L. decandrum extracts ranged from 2-4 days.
12. Risk factors of pulmonary tuberculosis in tea garden communities of Assam, India
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Chelleng, P. K., Devi, K. R., Borbora, D., Chetia, M., Saikia, A., Mahanta, J., and Kanwar Narain
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Adult ,Male ,Rural Population ,Adolescent ,lcsh:R ,Age Factors ,India ,lcsh:Medicine ,Agriculture ,Middle Aged ,Camellia sinensis ,Logistic Models ,Sex Factors ,Socioeconomic Factors ,Risk Factors ,Surveys and Questionnaires ,Correspondence ,Epidemiological Monitoring ,Odds Ratio ,Cluster Analysis ,Humans ,Female ,Tuberculosis, Pulmonary
13. Urban rural differences in prevalence of self-reported diabetes in India—The WHO–ICMR Indian NCD risk factor surveillance
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Mohan, Viswanathan, Mathur, Prashant, Deepa, Raj, Deepa, Mohan, Shukla, D.K., Menon, Geetha R., Anand, Krishnan, Desai, Nimesh G., Joshi, Prashant P., Mahanta, J., Thankappan, K.R., and Shah, Bela
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DIABETES , *ENDOCRINE diseases , *MEDICAL screening - Abstract
Abstract: Recent reports show strikingly high prevalence of diabetes among urban Asian Indians; however, there are very few studies comparing urban, peri-urban and rural prevalence rates of diabetes and their risk factors at the national level. This study is a part of the national non-communicable diseases (NCD) risk factor surveillance conducted in different geographical locations (North, South, East, West/Central) in India between April 2003 and March 2005. A total of 44,523 individuals (age: 15–64 years) inclusive of 15,239 from urban, 15,760 from peri-urban/slum and 13,524 from rural areas were recruited. Major risk factors were studied using modified WHO STEPS approach. Diabetes was diagnosed based on self-reported diabetes diagnosed by a physician. The lowest prevalence of self-reported diabetes was recorded in rural (3.1%) followed by peri-urban/slum (3.2%) and the highest in urban areas (7.3%, odds ratio (OR) for urban areas: 2.48, 95% confidence interval (CI): 2.21–2.79, p <0.001). Urban residents with abdominal obesity and sedentary activity had the highest prevalence of self-reported diabetes (11.3%) while rural residents without abdominal obesity performing vigorous activity had the lowest prevalence (0.7%). In conclusion, this nation-wide NCD risk factor surveillance study shows that the prevalence of self-reported diabetes is higher in urban, intermediate in peri-urban and lowest in rural areas. Urban residence, abdominal obesity and physical inactivity are the risk factors associated with diabetes in this study. [Copyright &y& Elsevier]
- Published
- 2008
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