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5 results on '"R., Altobelli"'

1. [Critical evaluation of the possibility of predicting atopy in the neonatal period].

Author

Altobelli R, Ottolenghi A, and Premate R

Subjects
Humans, Hypersensitivity diagnosis, Risk, Fetal Blood immunology, Hypersensitivity genetics, Immunoglobulin E analysis, Infant, Newborn
Abstract

On a sample of 35 healthy newborns the authors have determined the IgE in the blood of the umbilical cord, using the PRIST method. A geometric average of 1.152 +/- 0.117 was obtained. No statistically significant difference appeared between the two groups, which contained individuals with positive and negative allergic family anamnesis, respectively. Thus, the possibility of predicting neonatal atopy by IgE determination appears to be no better than can be deduced through an accurate family anamnesis. The observed differences in the IgE levels of the funicular blood might then be explained by physiological, paraphysiological and pathological motivations.

Published
1983

2. Human immunodeficiency virus type 1 infection and breast milk. The Italian Register for HIV Infection in Children

Author

M. de Martino, P. A. Tovo, L. Galli, C. Gabiano, G. Caramia, D. De Mattia, U. De Santis, M. Ruggeri, MG Zaniboni, M. Masi, G. Dell'Erba, P. Dallacasa, F. Baldi, M. Eisenstecken, A. Soresina, E. Bresciani, G. Quarta, C. Dessi, A. Corrias, F. Chiappe, P. Ibba, F. Di Gregorio, A. Sciotto, L. Tarallo, F. Lauria, M. Sticca, R. Berrino, P. Lusardi, P. Cocchi, A. Vierucci, D. Basetti, E. Boeri, S. Risso, GL Forni, U. Tondo, E. Micheletti, G. Gambaretto, A. Meo, M. Clerici Schoeller, LA Magni, P. Marchisio, GV Zuccotti, L. Simoni, A. Giovanniello, G. Ferraris, R. Altobelli, PL Mazzoni, M. Cellini, F. Ciccimarra, L. Esposito, G. Bona, S. Giordano, C. Giaquinto, V. Portelli, G. Benaglia, Di Caselli, G. Busti, R. Consolini, MT D. Fiore, C. Magnani, MT Cecchi, P. Falconieri, A. Martino, M. Stegagno, S. Livadiotti, C. Timpano, S. Bionda, S. Tulisso, A. Mazza, A. De Manzini, A. Pellegatta, GUARINO, ALFREDO, M., de Martino, P. A., Tovo, L., Galli, C., Gabiano, G., Caramia, D., De Mattia, U., De Santi, M., Ruggeri, Mg, Zaniboni, M., Masi, G., Dell'Erba, P., Dallacasa, F., Baldi, M., Eisenstecken, A., Soresina, E., Bresciani, G., Quarta, C., Dessi, A., Corria, F., Chiappe, P., Ibba, F., Di Gregorio, A., Sciotto, L., Tarallo, F., Lauria, M., Sticca, R., Berrino, P., Lusardi, P., Cocchi, A., Vierucci, D., Basetti, E., Boeri, S., Risso, Gl, Forni, U., Tondo, E., Micheletti, G., Gambaretto, A., Meo, M., Clerici Schoeller, La, Magni, P., Marchisio, Gv, Zuccotti, L., Simoni, A., Giovanniello, G., Ferrari, R., Altobelli, Pl, Mazzoni, M., Cellini, F., Ciccimarra, L., Esposito, Guarino, Alfredo, G., Bona, S., Giordano, C., Giaquinto, V., Portelli, G., Benaglia, Di, Caselli, G., Busti, R., Consolini, MT D., Fiore, C., Magnani, Mt, Cecchi, P., Falconieri, A., Martino, M., Stegagno, S., Livadiotti, C., Timpano, S., Bionda, S., Tulisso, A., Mazza, A., De Manzini, and A., Pellegatta

Subjects
Acquired Immunodeficiency Syndrome, Milk, Human, Dose-Response Relationship, Immunologic, Infant, Newborn, Mothers, Infectious Disease Transmission, Vertical, Breast Feeding, Italy, Risk Factors, Confidence Intervals, HIV-1, Odds Ratio, Humans, Female, Infant Food, Prospective Studies, Registries, Immunity, Maternally-Acquired, Algorithms
Abstract

Major questions are whether mothers infected with the Human Immunodeficiency Virus type 1 (HIV-1) transmit the virus through breast milk and the magnitude of the additional transmission risk. The demonstration of a dose-response effect is an epidemiological method to demonstrate causality. Thus, a study was carried out by the Italian Register for HIV Infection in Children on 961 children of known infection status. Duration of breast-feeding was considered as the level of exposure in 168 ever breast-fed children. Results showed that duration of practice significantly increased the risk of transmission. The adjusted infection odds ratio for one day of breast- versus exclusive formula-feeding was 1.19 with narrow confidence limits (1.10-1.28). In a second study by the Register on 556 children of known infection status and derived prospectively, an infection odds ratio of 2.55 (confidence interval: 1.03-6.37) was calculated in breast- versus exclusively formula-fed children. Several lines of evidence, including the above-mentioned data from the Italian Register for HIV Infection in Children, showed a contribution of breast-feeding to mother-to-child HIV-1 transmission. Thus, this practice is now discouraged in HIV-1 infected mothers living in industrialized societies where formula feeding is practical and attainable. Mode of feeding was known in 2183 children enrolled in the Register and born to HIV-1 infected mothers since 1981. It could be observed that feeding habits of at-risk infants changed in Italy in the middle 1980s, when a large majority of subjects was identified at birth.(ABSTRACT TRUNCATED AT 250 WORDS)

Published
1994

5. [Critical evaluation of the possibility of predicting atopy in the neonatal period]

Author

R, Altobelli, A, Ottolenghi, and R, Premate

Subjects
Risk, Hypersensitivity, Infant, Newborn, Humans, Immunoglobulin E, Fetal Blood
Abstract

On a sample of 35 healthy newborns the authors have determined the IgE in the blood of the umbilical cord, using the PRIST method. A geometric average of 1.152 +/- 0.117 was obtained. No statistically significant difference appeared between the two groups, which contained individuals with positive and negative allergic family anamnesis, respectively. Thus, the possibility of predicting neonatal atopy by IgE determination appears to be no better than can be deduced through an accurate family anamnesis. The observed differences in the IgE levels of the funicular blood might then be explained by physiological, paraphysiological and pathological motivations.

Published
1983

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