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Your search keyword '"Cutrupi, M. C."' showing total 2 results
Start Over Author "Cutrupi, M. C." Topic inflammation
2 results on '"Cutrupi, M. C."'

1. Inflammatory biomarkers and intellectual disability in patients with Down syndrome.

Author

Manti S, Cutrupi MC, Cuppari C, Ferro E, Dipasquale V, Di Rosa G, Chimenz R, La Rosa MA, Valenti A, and Salpietro V

Subjects
Adolescent, Biomarkers blood, C-Reactive Protein metabolism, Child, Child, Preschool, Cohort Studies, Down Syndrome blood, Female, HMGB1 Protein blood, Humans, Intellectual Disability blood, Italy, Male, Serum Amyloid A Protein metabolism, Down Syndrome complications, Inflammation blood, Inflammation complications, Intellectual Disability complications
Abstract

Background: Intellectual disability (ID) is part of the Down syndrome (DS) phenotypic spectrum, but the exact molecular pathophysiology of ID in individuals with DS is not yet fully understood, with many research hypotheses still unproven. Basing on previous studies (which suggested a possible role of altered inflammatory response in DS-related ID), we assessed the serum levels of a number of inflammatory biomarkers [serum amyloid A (SAA), C-reactive protein (C-RP), high mobility group box-1 (HMGB1)] in a cohort of individuals with DS and healthy controls., Methods: In total, 24 children diagnosed with DS and 12 healthy controls were enrolled, and all underwent detailed cognitive assessment. Also, serum SAA, C-RP and HMGB1 levels were measured in all recruited subjects and correlated to the severity of ID in the DS group., Results: Serum SAA, C-RP and HMGB1 values were found to be significantly higher in the DS group compared with the healthy subjects (P = 0.001). In addition, serum HMGB1 levels positively correlated with C-RP and SAA in the DS group but not in the healthy controls. Only serum C-RP levels resulted inversely correlated (P < 0.01) with intelligence quotient (IQ); conversely, significant statistical correlations between serum SAA levels and IQ (as well as between HMGB1 and IQ) have been not found (P > 0.05)., Conclusions: The levels of the determined markers were higher in DS individuals compared with (cognitively) healthy subjects, and CRP showed a negative correlation with IQ in children with DS., (© 2018 MENCAP and International Association of the Scientific Study of Intellectual and Developmental Disabilities and John Wiley & Sons Ltd.)

Published
2018
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2. Inflammatory biomarkers and intellectual disability in patients with Down syndrome

Author

Manti, S., Cutrupi, M. C., Cuppari, C., Ferro, E., Dipasquale, V., Di Rosa, G., Chimenz, R., La Rosa, M. A., Valenti, A., and Salpietro, V.

Subjects
Inflammation, Male, Serum Amyloid A Protein, Adolescent, Down syndrome, serum amyloid A, C-reactive protein, Down syndrome, children, high mobility group box-1, intellectual quotient, serum amyloid A, C-reactive protein, children, high mobility group box-1, intellectual quotient, Cohort Studies, Italy, Child, Preschool, Intellectual Disability, Humans, Female, HMGB1 Protein, Child, Biomarkers
Abstract

Intellectual disability (ID) is part of the Down syndrome (DS) phenotypic spectrum, but the exact molecular pathophysiology of ID in individuals with DS is not yet fully understood, with many research hypotheses still unproven. Basing on previous studies (which suggested a possible role of altered inflammatory response in DS-related ID), we assessed the serum levels of a number of inflammatory biomarkers [serum amyloid A (SAA), C-reactive protein (C-RP), high mobility group box-1 (HMGB1)] in a cohort of individuals with DS and healthy controls.In total, 24 children diagnosed with DS and 12 healthy controls were enrolled, and all underwent detailed cognitive assessment. Also, serum SAA, C-RP and HMGB1 levels were measured in all recruited subjects and correlated to the severity of ID in the DS group.Serum SAA, C-RP and HMGB1 values were found to be significantly higher in the DS group compared with the healthy subjects (P = 0.001). In addition, serum HMGB1 levels positively correlated with C-RP and SAA in the DS group but not in the healthy controls. Only serum C-RP levels resulted inversely correlated (P 0.01) with intelligence quotient (IQ); conversely, significant statistical correlations between serum SAA levels and IQ (as well as between HMGB1 and IQ) have been not found (P 0.05).The levels of the determined markers were higher in DS individuals compared with (cognitively) healthy subjects, and CRP showed a negative correlation with IQ in children with DS.

Published
2018

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