1. Plasma galectin-9 relates to cognitive performance and inflammation among adolescents with vertically acquired HIV.
- Author
-
Moar P, Linn K, Premeaux TA, Bowler S, Sardarni UK, Gopalan BP, Shwe EE, San T, Han H, Clements D, Hlaing CS, Kyu EH, Thair C, Mar YY, Nway N, Mannarino J, Bolzenius J, Mar S, Aye AMM, Tandon R, Paul R, and Ndhlovu LC
- Subjects
- Humans, Male, Adolescent, Female, Cross-Sectional Studies, India, Cognition, Plasma, Flow Cytometry, Immunoassay, Infectious Disease Transmission, Vertical, Biomarkers blood, Child, Galectins blood, HIV Infections drug therapy, HIV Infections psychology, HIV Infections complications, Inflammation blood
- Abstract
Objective: Adolescents with perinatally acquired HIV (AWH) are at an increased risk of poor cognitive development yet the underlying mechanisms remain unclear. Circulating galectin-9 (Gal-9) has been associated with increased inflammation and multimorbidity in adults with HIV despite antiretroviral therapy (ART); however, the relationship between Gal-9 in AWH and cognition remain unexplored., Design: A cross-sectional study of two independent age-matched cohorts from India [AWH on ART ( n = 15), ART-naive ( n = 15), and adolescents without HIV (AWOH; n = 10)] and Myanmar [AWH on ART ( n = 54) and AWOH ( n = 22)] were studied. Adolescents from Myanmar underwent standardized cognitive tests., Methods: Plasma Gal-9 and soluble mediators were measured by immunoassays and cellular immune markers by flow cytometry. We used Mann-Whitney U tests to determine group-wise differences, Spearman's correlation for associations and machine learning to identify a classifier of cognitive status (impaired vs. unimpaired) built from clinical (age, sex, HIV status) and immunological markers., Results: Gal-9 levels were elevated in ART-treated AWH compared with AWOH in both cohorts (all P < 0.05). Higher Gal-9 in AWH correlated with increased levels of inflammatory mediators (sCD14, TNFα, MCP-1, IP-10, IL-10) and activated CD8 + T cells (all P < 0.05). Irrespective of HIV status, higher Gal-9 levels correlated with lower cognitive test scores in multiple domains [verbal learning, visuospatial learning, memory, motor skills (all P < 0.05)]. ML classification identified Gal-9, CTLA-4, HVEM, and TIM-3 as significant predictors of cognitive deficits in adolescents [mean area under the curve (AUC) = 0.837]., Conclusion: Our results highlight a potential role of Gal-9 as a biomarker of inflammation and cognitive health among adolescents with perinatally acquired HIV., (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.)
- Published
- 2024
- Full Text
- View/download PDF