1. Innate Immunity and Inflammation Post-Stroke: An α7-Nicotinic Agonist Perspective.
- Author
-
Neumann S, Shields NJ, Balle T, Chebib M, and Clarkson AN
- Subjects
- Animals, Humans, Inflammation drug therapy, Inflammation pathology, Myeloid Cells drug effects, Myeloid Cells immunology, Myeloid Cells pathology, Stroke drug therapy, Stroke pathology, alpha7 Nicotinic Acetylcholine Receptor agonists, Immunity, Innate drug effects, Inflammation etiology, Inflammation immunology, Stroke complications, Stroke immunology, alpha7 Nicotinic Acetylcholine Receptor immunology
- Abstract
Stroke is one of the leading causes of death and long-term disability, with limited treatment options available. Inflammation contributes to damage tissue in the central nervous system across a broad range of neuropathologies, including Alzheimer's disease, pain, Schizophrenia, and stroke. While the immune system plays an important role in contributing to brain damage produced by ischemia, the damaged brain, in turn, can exert a powerful immune-suppressive effect that promotes infections and threatens the survival of stroke patients. Recently the cholinergic anti-inflammatory pathway, in particular its modulation using α7-nicotinic acetylcholine receptor (α7-nAChR) ligands, has shown potential as a strategy to dampen the inflammatory response and facilitate functional recovery in stroke patients. Here we discuss the current literature on stroke-induced inflammation and the effects of α7-nAChR modulators on innate immune cells.
- Published
- 2015
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