Search

Current study was aimed to validate traditional claim of Tamra bhasma (TB) as an antinflammatory agent by investigating the preclinical anti-inflammatory activity of TB. Initially, TB was characterised by some traditional and modern parameters including scanning electron microscopy (SEM), energy dispersive x-ray analysis (EDAX) and X-ray diffraction (XRD). Subsequently, its anti-inflammatory activity was evaluated in carrageenan, cotton pellet and complete Freund’s adjuvant (CFA) model. The % inhibition of paw oedema and granuloma tissue, blood and tissue related pharmacological evaluations were performed for assessment of anti-inflammatory activity. The SEM, EDAX and XRD confirmed presence of nanoparticulate copper as its sulfide or oxide form in bhasma. The changes produced by carrageenan and CFA in animals were reversed significantly in TB treated animals throughout the study. The results suggest that TB has a potential anti-inflammatory activity. [ABSTRACT FROM AUTHOR]