1. HMGB1 in inflammation and cancer.
- Author
-
Wang S and Zhang Y
- Subjects
- Apoptosis physiology, Autophagy physiology, Carcinogenesis, Cell Nucleus metabolism, Cell Survival physiology, Chemoradiotherapy, Cytokines metabolism, Cytoplasm metabolism, DNA Repair, Humans, Immunity physiology, Immunotherapy, Neoplasms therapy, HMGB1 Protein physiology, Inflammation metabolism, Neoplasm Proteins physiology, Neoplasms metabolism
- Abstract
High mobility group box 1 (HMGB1) is a non-histone chromatin-associated protein widely distributed in eukaryotic cells and is involved in DNA damage repair and genomic stability maintenance. In response to stimulus like bacteria or chemoradiotherapy, HMGB1 can translocate to extracellular context as a danger alarmin, activate the immune response, and participate in the regulation of inflammation and cancer progression.
- Published
- 2020
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