1. Clinical Significance of CD147 in Children with Inflammatory Bowel Disease.
- Author
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Wang H, Ye J, Liu R, Chen G, Zhao J, Huang L, Yang F, Li M, Zhang S, Jingxie, Xiong L, Chen H, Xu Y, Su M, Xie Y, Li S, Zheng F, Geng L, Xu W, and Gong S
- Subjects
- Basigin blood, Child, Epithelial Cells metabolism, Epithelial Cells pathology, Female, Humans, Inflammatory Bowel Diseases blood, Intestinal Mucosa metabolism, Intestinal Mucosa pathology, Male, Basigin metabolism, Inflammatory Bowel Diseases metabolism
- Abstract
Background: CD147/basigin (Bsg), a transmembrane glycoprotein, activates matrix metalloproteinases and promotes inflammation., Objective: The aim of this study is to explore the clinical significance of CD147 in the pathogenesis of inflammatory bowel disease (IBD)., Results: In addition to monocytes, the clinical analysis showed that there is no significance obtained in leucocyte, neutrophil, eosinophil, basophil, and erythrocyte between IBD and controls. Immunohistochemistry analysis showed that CD147 was increased in intestinal tissue of patients with active IBD compared to that in the control group. What is more, CD147 is involved in intestinal barrier function and intestinal inflammation, which was attributed to the fact that it has an influence on MCT4 expression, a regulator of intestinal barrier function and intestinal inflammation, in HT-29 and CaCO2 cells. Most importantly, serum level of CD147 content is higher in active IBD than that in inactive IBD or healthy control, which could be a biomarker of IBD., Conclusion: The data suggested that increased CD147 level could be a biomarker of IBD in children., Competing Interests: The authors declared that they have no competing interests., (Copyright © 2020 Hongli Wang et al.)
- Published
- 2020
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