1. Effectiveness of influenza vaccines in children aged 6 to 59 months: a test-negative case-control study at primary care and hospital level, Spain 2023/24.
- Author
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Pérez-Gimeno G, Mazagatos C, Lorusso N, Basile L, Martínez-Pino I, Corpas Burgos F, Batalla Rebolla N, Rumayor Zarzuelo MB, Andreu Ivorra B, Giménez Duran J, Castrillejo D, Guiu Cañete I, Huerta Huerta M, García Becerril M, Ramos Marín V, Casas I, Pozo F, and Monge S
- Subjects
- Humans, Spain epidemiology, Case-Control Studies, Infant, Child, Preschool, Female, Male, Vaccine Efficacy, Hospitalization statistics & numerical data, Seasons, Influenza A Virus, H3N2 Subtype immunology, Influenza A Virus, H3N2 Subtype isolation & purification, Influenza B virus immunology, Influenza B virus isolation & purification, Hospitals, Influenza Vaccines administration & dosage, Influenza Vaccines immunology, Influenza, Human prevention & control, Influenza, Human epidemiology, Primary Health Care, Sentinel Surveillance, Influenza A Virus, H1N1 Subtype immunology, Influenza A Virus, H1N1 Subtype isolation & purification, Vaccination statistics & numerical data
- Abstract
During 2023/24, all children aged 6 to 59 months were targeted for seasonal influenza vaccination in Spain nationally. Using a test-negative case-control design with sentinel surveillance data, we estimated adjusted influenza vaccine effectiveness (IVE) against any influenza type to be 70% (95% confidence interval (CI): 51 to 81%) for primary care patients with acute respiratory illness (ARI) and 77% (95% CI: 21 to 93%) for hospitalised patients with severe ARI. In primary care, where most subtyped viruses (61%; 145/237) were A(H1N1), adjusted IVE was 77% (95% CI: 56 to 88%) against A(H1N1)pdm09.
- Published
- 2024
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