Search

Your search keyword '"Mache, Christin"' showing total 2 results
Start Over Author "Mache, Christin" Topic influenza
2 results on '"Mache, Christin"'

1. Analysis of SARS-CoV-2 replication in explant cultures of the human upper respiratory tract reveals broad tissue tropism of wild-type and B.1.1.7 variant viruses

Author

Schulze, Jessica, Mache, Christin, Balázs, Anita, Frey, Doris, Niemeyer, Daniela, Olze, Heidi, Dommerich, Steffen, Drosten, Christian, Hocke, Andreas C, Mall, Marcus A, Hippenstiel, Stefan, and Wolff, Thorsten

Subjects
SARS-CoV-2, viruses, Brief Report, Respiratory System, COVID-19, Virus Replication, Influenza, Trachea, Viral Tropism, AcademicSubjects/MED00290, Variants of Concern, Humans, Upper Respiratory Tract, Respiratory Tract Infections
Abstract

The upper respiratory tract (URT) is the primary entry site for severe acute respiratory syndrome 2 (SARS-CoV-2) and other respiratory viruses, but its involvement in viral amplification and pathogenesis remains incompletely understood.In this study, we investigated primary nasal epithelial cultures, as well as vital explanted tissues, to scrutinize the tropism of wild-type SARS-CoV-2 and the recently emerged B.1.1.7 variant.Our analyses revealed a widespread replication competence of SARS-CoV-2 in polarized nasal epithelium as well as in the examined URT and salivary gland tissues, which was also shared by the B.1.1.7 virus.In our analyses, we highlighted the active role of these anatomic sites in coronavirus disease 2019.

Published
2021

2. Analysis of Severe Acute Respiratory Syndrome 2 Replication in Explant Cultures of the Human Upper Respiratory Tract Reveals Broad Tissue Tropism of Wild-Type and B.1.1.7 Variant Viruses.

Author

Schulze, Jessica, Mache, Christin, Balázs, Anita, Frey, Doris, Niemeyer, Daniela, Olze, Heidi, Dommerich, Steffen, Drosten, Christian, Hocke, Andreas C, Mall, Marcus A, Hippenstiel, Stefan, and Wolff, Thorsten

Subjects
*COVID-19, *SARS-CoV-2, *NASAL mucosa, *TROPISMS, *GENETIC mutation, *RESPIRATORY infections, *CULTURES (Biology), *RESEARCH funding, *SARS disease
Abstract

Background: The upper respiratory tract (URT) is the primary entry site for severe acute respiratory syndrome 2 (SARS-CoV-2) and other respiratory viruses, but its involvement in viral amplification and pathogenesis remains incompletely understood.Methods: In this study, we investigated primary nasal epithelial cultures, as well as vital explanted tissues, to scrutinize the tropism of wild-type SARS-CoV-2 and the recently emerged B.1.1.7 variant.Results: Our analyses revealed a widespread replication competence of SARS-CoV-2 in polarized nasal epithelium as well as in the examined URT and salivary gland tissues, which was also shared by the B.1.1.7 virus.Conclusions: In our analyses, we highlighted the active role of these anatomic sites in coronavirus disease 2019. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results