1. Plastic Bronchitis of Human Bocavirus 1 Detected by Comprehensive Polymerase Chain Reaction of Mucus Casts.
- Author
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Yabushita H, Otake S, Iida S, Katano H, Suzuki T, and Kasai M
- Subjects
- Humans, Child, Infant, Multiplex Polymerase Chain Reaction, Plastics, Human bocavirus genetics, Influenza A Virus, H1N1 Subtype, Respiratory Tract Infections, Bronchitis diagnosis, Bronchitis complications, Influenza A virus, Respiratory Syncytial Virus, Human, Parvoviridae Infections diagnosis, Parvoviridae Infections complications
- Abstract
Plastic bronchitis (PB) is a rare and severe respiratory disease characterized by the formation of branching mucus casts, resulting in airway obstruction. PB can be divided into two types. Type 1 PB is primarily caused by inflammatory casts that result from allergic diseases. In type 2 PB, mucinous casts are produced in association with congenital heart disease. PB is also associated with viral respiratory infections, particularly the influenza A (H1N1) pdm09 virus, which is the most common pathogen affecting pediatric patients. Herein, we report a case of severe type 1 PB caused by human bocavirus (HBoV)1 in a child. Multiplex polymerase chain reaction (PCR) of a nasopharyngeal swab revealed the presence of respiratory syncytial virus and human parainfluenza virus 3. However, no viruses other than HBoV1 were detected in mucus casts by real-time PCR. Consequently, we suggest that HBoV can cause PB in pediatric patients, and direct and comprehensive PCR of bronchial casts may be useful for identifying the etiologic agents.
- Published
- 2023
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