1. Effect of yearly vaccinations with live, attenuated, cold-adapted, trivalent, intranasal influenza vaccines on antibody responses in children.
- Author
-
Bernstein DI, Yan L, Treanor J, Mendelman PM, and Belshe R
- Subjects
- Administration, Intranasal, Child, Preschool, Cold Temperature, Hemagglutination Inhibition Tests methods, Humans, Infant, Influenza A virus immunology, Influenza B virus immunology, Influenza, Human immunology, Time Factors, Vaccination, Vaccines, Attenuated immunology, Vaccines, Combined immunology, Antibodies, Viral blood, Influenza Vaccines administration & dosage, Influenza Vaccines immunology, Influenza, Human prevention & control
- Abstract
Background: The cold-adapted, trivalent influenza vaccine (CAIV-T) may become an option for annual vaccination. However, there is little information regarding the immune response to repeated immunization with CAIV-T., Objective: To determine the antibody response to repeated immunization with CAIV-T and to compare this with the response after the first CAIV-T immunization., Design and Methods: Healthy children were offered CAIV-T immunization for 4 consecutive years, and blood samples were taken from a subset in Years 1, 2 and 4. In Year 4, 156 similarly aged children who had not received influenza vaccine previously were immunized with the same CAIV-T., Results: The H3N2 and B components of the CAIV-T induced high antibody titers in Year 1 that were maintained during 4 years. The H1N1 titers were lower than the H3N2 or B titers. Comparison of the group immunized for 4 consecutive years with the group immunized for the first time revealed the following: (1) before immunization yearly immunized subjects were more likely to be seropositive to each of the three vaccine strains than those immunized for the first time (P < 0.05 for each); (2) after immunization the percentage of seropositive subjects to each of the strains was similar; (3) after immunization titers were higher in the subjects immunized for the first time than those immunized yearly (P < 0.05 for H3N2 and B)., Conclusion: Yearly vaccination with CAIV-T induced high antibody titers, especially to the H3N2 and B strains in the vaccines. The titers in those immunized with CAIV-T for the first time were higher than in those immunized for 4 consecutive years.
- Published
- 2003
- Full Text
- View/download PDF