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Your search keyword '"McCoy, Lisa S."' showing total 3 results
Start Over Author "McCoy, Lisa S." Topic inosine
3 results on '"McCoy, Lisa S."'

2. Enzymatic Interconversion of Isomorphic Fluorescent Nucleosides: Adenosine Deaminase Transforms an Adenosine Analogue into an Inosine Analogue

Author

Sinkeldam, Renatus W, McCoy, Lisa S, Shin, Dongwon, and Tor, Yitzhak

Subjects
Adenosine, Adenosine Deaminase, Inosine, Nucleosides, adenosine deamination, fluorescence, high-throughput screening, kinetics, nucleosides, Chemical Sciences, Organic Chemistry
Abstract

Adenosine deaminase, a major enzyme involved in purine metabolism, converts an isomorphic fluorescent analogue of adenosine (thA) to an isomorphic inosine analogue (thI), which possesses distinct spectral features, allowing one to monitor the enzyme-catalyzed reaction and its inhibition in real time. The utility of this sensitive fluorescently-monitored transformation for the high throughput detection and analysis of ADA inhibitors is demonstrated.

Published
2013

3. Enzymatic Interconversion of Isomorphic Fluorescent Nucleosides: Adenosine Deaminase Transforms thA to thI, Two Distinct Fluorophores

Author

Sinkeldam, Renatus W., McCoy, Lisa S., Shin, Dongwon, and Tor, Yitzhak

Subjects
Adenosine, Adenosine Deaminase, Nucleosides, Article, Inosine
Abstract

Adenosine deaminase, a major enzyme involved in purine metabolism, converts an isomorphic fluorescent analogue of adenosine (thA) to an isomorphic inosine analogue (thI), which possesses distinct spectral features, allowing one to monitor the enzyme-catalyzed reaction and its inhibition in real time. The utility of this sensitive fluorescently-monitored transformation for the high throughput detection and analysis of ADA inhibitors is demonstrated.

Published
2013

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