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170 results on '"SHULMAN, GERALD I."'

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1. Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice.

2. Insulin-stimulated endoproteolytic TUG cleavage links energy expenditure with glucose uptake.

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3. One-leg inactivity induces a reduction in mitochondrial oxidative capacity, intramyocellular lipid accumulation and reduced insulin signalling upon lipid infusion: a human study with unilateral limb suspension.

4. Mechanistic Links between Obesity, Insulin, and Cancer.

5. Adipose glucocorticoid action influences whole-body metabolism via modulation of hepatic insulin action.

6. Dehydration and insulinopenia are necessary and sufficient for euglycemic ketoacidosis in SGLT2 inhibitor-treated rats.

7. Mechanisms of Insulin Action and Insulin Resistance.

8. PKCε contributes to lipid-induced insulin resistance through cross talk with p70S6K and through previously unknown regulators of insulin signaling.

9. Mechanism for leptin's acute insulin-independent effect to reverse diabetic ketoacidosis.

10. Hypophosphatemia promotes lower rates of muscle ATP synthesis.

11. MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels.

12. Imeglimin lowers glucose primarily by amplifying glucose-stimulated insulin secretion in high-fat-fed rodents.

13. Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance.

14. Acetylation of TUG protein promotes the accumulation of GLUT4 glucose transporters in an insulin-responsive intracellular compartment.

15. Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids.

16. Mitochondrial GTP insensitivity contributes to hypoglycemia in hyperinsulinemia hyperammonemia by inhibiting glucagon release.

17. Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression.

18. Muscle-specific activation of Ca(2+)/calmodulin-dependent protein kinase IV increases whole-body insulin action in mice.

19. Hyperglucagonemia precedes a decline in insulin secretion and causes hyperglycemia in chronically glucose-infused rats.

20. Influence of the hepatic eukaryotic initiation factor 2alpha (eIF2alpha) endoplasmic reticulum (ER) stress response pathway on insulin-mediated ER stress and hepatic and peripheral glucose metabolism.

21. FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis.

22. Diabetes in mice with selective impairment of insulin action in Glut4-expressing tissues.

23. Cellularity and adipogenic profile of the abdominal subcutaneous adipose tissue from obese adolescents: association with insulin resistance and hepatic steatosis.

24. Deletion of the alpha-arrestin protein Txnip in mice promotes adiposity and adipogenesis while preserving insulin sensitivity.

25. Phosphoenolpyruvate cycling via mitochondrial phosphoenolpyruvate carboxykinase links anaplerosis and mitochondrial GTP with insulin secretion.

26. SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats.

27. Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets.

28. Increased energy expenditure and insulin sensitivity in the high bone mass DeltaFosB transgenic mice.

29. Skeletal muscle-specific deletion of lipoprotein lipase enhances insulin signaling in skeletal muscle but causes insulin resistance in liver and other tissues.

30. Dual role of proapoptotic BAD in insulin secretion and beta cell survival.

31. Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity.

32. n-3 Fatty acids preserve insulin sensitivity in vivo in a peroxisome proliferator-activated receptor-alpha-dependent manner.

33. Mitochondrial GTP regulates glucose-stimulated insulin secretion.

34. Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo.

35. Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease.

36. Cytosolic and mitochondrial malic enzyme isoforms differentially control insulin secretion.

37. Urocortin 2 modulates glucose utilization and insulin sensitivity in skeletal muscle.

38. Targeting foxo1 in mice using antisense oligonucleotide improves hepatic and peripheral insulin action.

39. The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis.

40. Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty Acyl-CoAs and insulin action in type 2 diabetic patients.

41. Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents.

42. Hormone-sensitive lipase knockout mice have increased hepatic insulin sensitivity and are protected from short-term diet-induced insulin resistance in skeletal muscle and heart.

43. The "obese insulin-sensitive" adolescent: importance of adiponectin and lipid partitioning.

44. 13C NMR isotopomer analysis of anaplerotic pathways in INS-1 cells.

45. Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action.

46. Effects of rexinoids on glucose transport and insulin-mediated signaling in skeletal muscles of diabetic (db/db) mice.

47. Genetic modulation of PPARgamma phosphorylation regulates insulin sensitivity.

48. Defective activation of skeletal muscle and adipose tissue lipolysis in type 1 diabetes mellitus during hypoglycemia.

49. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle.

50. Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats.