1. Glutathione depletion prevents diet-induced obesity and enhances insulin sensitivity.
- Author
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Findeisen HM, Gizard F, Zhao Y, Qing H, Jones KL, Cohn D, Heywood EB, and Bruemmer D
- Subjects
- Animals, Antioxidants metabolism, Behavior, Animal, Blood Glucose metabolism, Homeostasis, Locomotion, Mice, Mice, Inbred C57BL, Obesity etiology, Signal Transduction, Diet adverse effects, Energy Metabolism, Glutathione metabolism, Insulin Resistance, Obesity prevention & control, Reactive Oxygen Species metabolism
- Abstract
Excessive accumulation of reactive oxygen species (ROS) in adipose tissue has been implicated in the development of insulin resistance and type 2 diabetes. However, emerging evidence suggests a physiologic role of ROS in cellular signaling and insulin sensitivity. In this study, we demonstrate that pharmacologic depletion of the antioxidant glutathione in mice prevents diet-induced obesity, increases energy expenditure and locomotor activity, and enhances insulin sensitivity. These observations support a beneficial role of ROS in glucose homeostasis and warrant further research to define the regulation of metabolism and energy balance by ROS.
- Published
- 2011
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