1. My scientific journey to and through extracellular matrix.
- Author
-
Ruoslahti E
- Subjects
- Animals, Humans, Extracellular Matrix Proteins metabolism, Extracellular Matrix Proteins genetics, Peptide Library, Extracellular Matrix metabolism, Fibronectins metabolism, Fibronectins genetics, Fibronectins chemistry, Integrins metabolism, Integrins genetics, Oligopeptides metabolism, Oligopeptides genetics, Oligopeptides chemistry
- Abstract
This article recounts my journey as a scientist in the early days of extracellular matrix research through the discovery of fibronectin, the RGD sequence as a key recognition motif in fibronectin and other adhesion proteins, and isolation and cloning of integrins. I also discuss more recent work on identification of molecular "zip codes" by in vivo screening of peptide libraries expressed on phage, which led us right back to RGD and integrins. Many disease-specific zip codes have turned out to be based on altered expression of extracellular matrix molecules and integrins. Homing peptides and antibodies recognizing zip code molecules are being used in drug delivery applications, some of which have advanced into clinical trials., Competing Interests: Declaration of competing interest ER is a founder and shareholder, and Chairman of the Board of Directors, of Impilo Therapeutics, Inc., AivoCode Inc, and Precis Therapeutics, Inc. He is also shareholder of Lisata Therapeutics, Inc. Each of these companies works on bringing peptide-mediated drug targeting into the clinic., (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Published
- 2024
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