1. αvβ6-Fyn Kinase Promotes Epithelial Phenotype in SYF Cells.
- Author
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Lee C and Ramos DM
- Subjects
- Animals, Cell Line, Cell Movement, Epithelial Cells metabolism, Fibroblasts metabolism, Mice, Mitogen-Activated Protein Kinases metabolism, Phenotype, Antigens, Neoplasm genetics, Epithelial Cells cytology, Epithelial-Mesenchymal Transition, Fibroblasts cytology, Integrins genetics, Proto-Oncogene Proteins c-fyn genetics
- Abstract
The 5-year survival rate for patients with oral cancer remains at 50%, in large part due the high rate of post-treatment recurrence. In this study, we transfected epithelial-specific integrin αvβ6 and Fyn-kinase, a member of the Src-family kinases, into embryonic murine fibroblasts. In oral cancer, expression of αvβ6 is neo-expressed. Using a variety of in vitro assays, including cell migration and multicellular spheroid formation, we determined that these embryonic fibroblasts expressing αvβ6 and Fyn-kinase were able to acquire an epithelial phenotype. This is in direct contrast to human oral SCC, where expression of αvβ6 with Fyn-kinase promotes epithelial to mesenchymal transition. This demonstrates that signaling pathways can be species-specific., (Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Published
- 2018
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